1. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
- Author
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Iliyan Ivanov, Premika S.W. Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Paul D. Arnold, Srinivas Balachander, Justin T. Baker, Nerisa Banaj, Nuria Bargalló, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Silvia Brem, Brian P. Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K. Cho, Sara Dallaspezia, Damiaan Denys, Juliana B. Diniz, Benjamin A. Ely, Jamie D. Feusner, Sónia Ferreira, Kate D. Fitzgerald, Martine Fontaine, Patricia Gruner, Gregory L. Hanna, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Keisuke Ikari, Anthony James, Fern Jaspers-Fayer, Hongyan Jiang, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M. Menchón, Luciano Minuzzi, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Sanghoon Oh, Chris Perriello, John C. Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Y.C. Janardhan Reddy, Daniela Rodriguez Manrique, Yuki Sakai, Eiji Shimizu, H. Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, David F. Tolin, Daan van Rooij, Dick J. Veltman, Ysbrand D. van der Werf, Guido A. van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Mojtaba Zarei, Fengrui Zhang, Qing Zhao, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Joseph O'Neill, Sara Poletti, Egill Axfjord Fridgeirsson, Toshikazu Ikuta, Stella J. de Wit, Chris Vriend, Selina Kasprzak, Masaru Kuno, Jumpei Takahashi, Euripedes C. Miguel, Roseli G. Shavitt, Morgan Hough, Jose C. Pariente, Ana E. Ortiz, Sara Bertolín, Eva Real, Cinto Segalàs, Pedro Silva Moreira, Nuno Sousa, Jin Narumoto, Kei Yamada, Jinsong Tang, Jean-Paul Fouche, Taekwan Kim, Sunah Choi, Minji Ha, Sunghyun Park, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Systems & Network Neuroscience, Amsterdam Neuroscience - Neurodegeneration, Adult Psychiatry, Child Psychiatry, Paediatric Psychosocial Care, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Graduate School, Ivanov, Iliyan, Boedhoe, Premika S W, Abe, Yoshinari, Alonso, Pino, Ameis, Stephanie H, Arnold, Paul D, Balachander, Sriniva, Baker, Justin T, Banaj, Nerisa, Bargalló, Nuria, Batistuzzo, Marcelo C, Benedetti, Francesco, Beucke, Jan C, Bollettini, Irene, Brem, Silvia, Brennan, Brian P, Buitelaar, Jan, Calvo, Rosa, Cheng, Yuqi, Cho, Kang Ik K, Dallaspezia, Sara, Denys, Damiaan, Diniz, Juliana B, Ely, Benjamin A, Feusner, Jamie D, Ferreira, Sónia, Fitzgerald, Kate D, Fontaine, Martine, Gruner, Patricia, Hanna, Gregory L, Hirano, Yoshiyuki, Hoexter, Marcelo Q, Huyser, Chaim, Ikari, Keisuke, James, Anthony, Jaspers-Fayer, Fern, Jiang, Hongyan, Kathmann, Norbert, Kaufmann, Christian, Kim, Minah, Koch, Kathrin, Kwon, Jun Soo, Lázaro, Luisa, Liu, Yanni, Lochner, Christine, Marsh, Rachel, Martínez-Zalacaín, Ignacio, Mataix-Cols, David, Menchón, José M, Minuzzi, Luciano, Morer, Astrid, Morgado, Pedro, Nakagawa, Akiko, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswamy, Janardhanan C, Nurmi, Erika L, Oh, Sanghoon, Perriello, Chri, Piacentini, John C, Picó-Pérez, Maria, Piras, Fabrizio, Piras, Federica, Reddy, Y C Janardhan, Manrique, Daniela Rodriguez, Sakai, Yuki, Shimizu, Eiji, Simpson, H Blair, Soreni, Noam, Soriano-Mas, Carle, Spalletta, Gianfranco, Stern, Emily R, Stevens, Michael C, Stewart, S Evelyn, Szeszko, Philip R, Tolin, David F, van Rooij, Daan, Veltman, Dick J, van der Werf, Ysbrand D, van Wingen, Guido A, Venkatasubramanian, Ganesan, Walitza, Susanne, Wang, Zhen, Watanabe, Anri, Wolters, Lidewij H, Xu, Xiufeng, Yun, Je-Yeon, Zarei, Mojtaba, Zhang, Fengrui, Zhao, Qing, Jahanshad, Neda, Thomopoulos, Sophia I, Thompson, Paul M, Stein, Dan J, van den Heuvel, Odile A, and O'Neill, Joseph
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Obsessive-Compulsive Disorder ,Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] ,OCD ,Psychotropics ,Longevity ,SRIs ,Magnetic Resonance Imaging ,Benzodiazepines ,Psychiatry and Mental health ,Clinical Psychology ,Age ,Cross-Sectional Studies ,Subcortical volumes ,130 000 Cognitive Neurology & Memory ,Child, Preschool ,Serotonin Uptake Inhibitors ,Humans ,Child ,Selective Serotonin Reuptake Inhibitors ,Aged ,Antipsychotic Agents - Abstract
Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6–65) was divided into six successive 6–10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6–13 and adults aged 50–65 with OCD taking SRIs (Cohen's d = −0.24 to −0.74). Volumes of putamen, pallidum (d = 0.18–0.40), and ventricles (d = 0.31–0.66) were greater in patients aged 20–29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = −0.27 to −1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20–29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
- Published
- 2022
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