1. Variation in the HTR1A and HTR2A genes and social adjustment in depressed patients
- Author
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Stuart Montgomery, Alessandro Serretti, Niki Antypa, Raffaella Calati, Julien Mendlewicz, Diana De Ronchi, Joseph Zohar, Siegfried Kasper, Daniela Amital, Othman Sentissi, Silvia Pellegrini, U. Moser, Daniel Souery, Antypa N, Calati R, Souery D, Pellegrini S, Sentissi O, Amital D, Moser U, Montgomery S, Kasper S, Zohar J, De Ronchi D, Mendlewicz J, Serretti A., Antypa, N, Calati, R, Souery, D, Pellegrini, S, Sentissi, O, Amital, D, Moser, U, Montgomery, S, Kasper, S, Zohar, J, De Ronchi, D, Mendlewicz, J, and Serretti, A
- Subjects
Adult ,Male ,medicine.medical_specialty ,Genotype ,Serotonin gene ,Genetic determinism ,Rs7997012 ,medicine ,Humans ,Receptor, Serotonin, 5-HT2A ,Allele ,Psychiatry ,Alleles ,Serotonin transporter ,Depression (differential diagnoses) ,rs6295 ,Aged ,Serotonin Plasma Membrane Transport Proteins ,Depressive Disorder, Major ,biology ,Depression ,Genetic Variation ,Middle Aged ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,Mood disorders ,Receptor, Serotonin, 5-HT1A ,biology.protein ,Antidepressant ,Female ,Psychology ,Social Adjustment ,Serotonin Plasma Membrane Transport Protein ,Human - Abstract
Background: Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders. Methods: We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156). Results: Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding. Limitations: These findings did not survive correction for multiple testing and should be interpreted with caution. Conclusion: Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. (C) 2013 Elsevier B.V. All rights reserved
- Published
- 2013