1. The Association of Psychological Well-Being With Sensory and Cognitive Function and Neuronal Health in Aging Adults.
- Author
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Merten, Natascha, Pinto, Aaron Alex, Paulsen, Adam J., Chen, Yanjun, Dillard, Lauren K., Fischer, Mary E., Ryff, Carol D., Schubert, Carla R., and Cruickshanks, Karen J.
- Subjects
DEAFNESS prevention ,NEURAL physiology ,RETINAL anatomy ,WELL-being ,SENSES ,HEARING ,STRUCTURAL equation modeling ,COGNITION disorders ,ACTIVE aging ,CROSS-sectional method ,MULTIPLE regression analysis ,HEALTH status indicators ,DESCRIPTIVE statistics ,VISUAL acuity ,SMELL disorders ,COGNITIVE testing ,VISION disorders ,MIDDLE age - Abstract
Objectives: Psychological well-being (PWB) may be a potential modifiable risk factor of age-related diseases. We aimed to determine associations of PWB with sensorineural and cognitive function and neuronal health in middle-aged adults. Methods: This study included 2039 Beaver Dam Offspring Study participants. We assessed PWB, hearing, visual acuity, contrast sensitivity impairment, olfactory impairment, cognition, and retinal (macular ganglion cell inner-plexiform layer, mGCIPL) thickness. Age-sex-education-adjusted multivariable linear, logistic regression, and generalized estimating equation models were used and then further adjusted for health-related confounders. Results: Individuals with higher PWB had better hearing functions, visual acuity, and thicker mGCIPL and reduced odds for hearing, contrast sensitivity and olfactory impairment in age-sex-education-adjusted models. Effects on mGCIPL and visual and olfactory measures decreased with adjustment. Higher PWB was associated with better cognition, better combined sensorineural-cognitive function, and decreased cognitive impairment. Discussion: Psychological well-being was associated with sensorineural-cognitive health indicating a potential of PWB interventions for healthy aging. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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