1. Production of Antifungal p-Aminobenzoic Acid in Lysobacter antibioticus OH13
- Author
-
Yangyang Zhao, Rongxian Hou, Pedro Laborda, Jun Ling, and Fengquan Liu
- Subjects
0301 basic medicine ,Antifungal ,Lysobacter antibioticus ,biology ,Chemistry ,medicine.drug_class ,030106 microbiology ,Fungi ,General Chemistry ,Lysobacter species ,Lysobacter ,Antimicrobial ,biology.organism_classification ,Fungicides, Industrial ,03 medical and health sciences ,030104 developmental biology ,Biochemistry ,P-Aminobenzoic acid ,medicine ,General Agricultural and Biological Sciences ,Antibacterial activity ,4-Aminobenzoic Acid ,Function (biology) ,Plant Diseases - Abstract
Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound was isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens. The genes involved in the synthetic route of this compound in OH13 were identified. Further, the production of pABA was optimized by modification of the carbon source using engineered L. antibioticus OH13 strains.
- Published
- 2017