1. Genome screen for asthma and bronchial hyperresponsiveness
- Author
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Timothy D. Howard, Elizabeth J. Ampleford, Deborah A. Meyers, O. Colin Stine, Dirkje S. Postma, Eugene R. Bleecker, Gerard H. Koppelman, Hajo Jongepier, and Groningen Research Institute for Asthma and COPD (GRIAC)
- Subjects
Adult ,Male ,bronchial hyperresponsiveness ,Passive smoking ,Genotype ,SUSCEPTIBILITY LOCI ,Genetic Linkage ,Immunology ,medicine.disease_cause ,smoking ,Atopy ,FOUNDER POPULATION ,ENVIRONMENTAL TOBACCO-SMOKE ,medicine ,Genetic predisposition ,Immunology and Allergy ,Humans ,Family ,Genetic Predisposition to Disease ,SERUM IGE ,Risk factor ,Asthma ,COPD ,LINKAGE ANALYSIS ,business.industry ,genome-wide sereen ,lung function ,asthma ,medicine.disease ,GENE ,Passive Smoke Exposure ,respiratory tract diseases ,CHROMOSOME 5Q31-Q33 ,LUNG-FUNCTION ,RESPIRATORY SYMPTOMS ,Bronchial hyperresponsiveness ,Chromosomes, Human, Pair 5 ,Female ,Tobacco Smoke Pollution ,Chromosomes, Human, Pair 3 ,Bronchial Hyperreactivity ,Lod Score ,business ,linkage ,WIDE SEARCH - Abstract
Background: Asthma is a common respiratory disease caused by the interaction of genetic susceptibility and exposure to various environmental factors. Passive smoke exposure, characterized by parental smoking, has been shown to be a risk factor for the development of atopy and asthma.Objective: We sought to perform a genome-wide linkage screen for asthma and bronchial hyperresponsiveness (BHR) and to determine the influence of passive tobacco smoke exposure during childhood on the results of genetic linkage studies to investigate gene-environment interactions.Methods: A genome-wide linkage screen for asthma and BHR was performed in 200 families ascertained through a parent with asthma. Analyses were performed separately for the entire sample and for the smoking-exposed and nonexposed families.Results: For asthma and BHR, the strongest evidence for linkage was observed for chromosomes 3p and 5q. The families in which the children were exposed to passive smoking accounted for the evidence for linkage of BHR to 5q (P Conclusion: The results from this study demonstrate that the influence of susceptibility genes for a common disease such as asthma might not be apparent unless there is the appropriate exposure to environmental stimuli, such as passive exposure to cigarette smoke. This approach should be useful for identification of asthma susceptibility genes.
- Published
- 2005