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Your search keyword '"Kleine‐Tebbe, Jörg"' showing total 19 results
Start Over Author "Kleine‐Tebbe, Jörg" Journal journal of allergy and clinical immunology
19 results on '"Kleine‐Tebbe, Jörg"'

1. Reply

Author

Mahler, Vera, primary, Esch, Robert E., additional, Kleine-Tebbe, Jörg, additional, Lavery, William J., additional, Plunkett, Greg, additional, Vieths, Stefan, additional, and Bernstein, David I., additional

Published
2019
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6. Reply

Author

Demoly, Pascal, primary and Kleine-Tebbe, Jörg, additional

Published
2016
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7. International Consensus on Allergen Immunotherapy II: Mechanisms, standardization, and pharmacoeconomics

Author

Jutel, Marek, primary, Agache, Ioana, additional, Bonini, Sergio, additional, Burks, A. Wesley, additional, Calderon, Moises, additional, Canonica, Walter, additional, Cox, Linda, additional, Demoly, Pascal, additional, Frew, Antony J., additional, O'Hehir, Robyn, additional, Kleine-Tebbe, Jörg, additional, Muraro, Antonella, additional, Lack, Gideon, additional, Larenas, Désirée, additional, Levin, Michael, additional, Martin, Bryan L., additional, Nelson, Harald, additional, Pawankar, Ruby, additional, Pfaar, Oliver, additional, van Ree, Ronald, additional, Sampson, Hugh, additional, Sublett, James L., additional, Sugita, Kazunari, additional, Du Toit, George, additional, Werfel, Thomas, additional, Gerth van Wijk, Roy, additional, Zhang, Luo, additional, Akdis, Mübeccel, additional, and Akdis, Cezmi A., additional

Published
2016
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9. International consensus on allergy immunotherapy

Author

Jutel, Marek, primary, Agache, Ioana, additional, Bonini, Sergio, additional, Burks, A. Wesley, additional, Calderon, Moises, additional, Canonica, Walter, additional, Cox, Linda, additional, Demoly, Pascal, additional, Frew, Antony J., additional, O'Hehir, Robin, additional, Kleine-Tebbe, Jörg, additional, Muraro, Antonella, additional, Lack, Gideon, additional, Larenas, Désirée, additional, Levin, Michael, additional, Nelson, Harald, additional, Pawankar, Ruby, additional, Pfaar, Oliver, additional, van Ree, Ronald, additional, Sampson, Hugh, additional, Santos, Alexandra F., additional, Du Toit, George, additional, Werfel, Thomas, additional, Gerth van Wijk, Roy, additional, Zhang, Luo, additional, and Akdis, Cezmi A., additional

Published
2015
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12. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase

Author

Maurer, Marcus, primary, Altrichter, Sabine, additional, Bieber, Thomas, additional, Biedermann, Tilo, additional, Bräutigam, Matthias, additional, Seyfried, Stefan, additional, Brehler, Randolf, additional, Grabbe, Jürgen, additional, Hunzelmann, Nicolas, additional, Jakob, Thilo, additional, Jung, Andreas, additional, Kleine-Tebbe, Jörg, additional, Mempel, Martin, additional, Meurer, Michael, additional, Reich, Kristian, additional, Ruëff, Franziska, additional, Schäkel, Knut, additional, Sengupta, Kaushik, additional, Sieder, Christian, additional, Simon, Jan C., additional, Wedi, Bettina, additional, Zuberbier, Torsten, additional, Mahler, Vera, additional, and Staubach, Petra, additional

Published
2011
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15. Histamine release from human basophils in vitro and IgE-binding to recombinant (r) pathogenesis-related (PR) Bet v 1-homologue soybean protein rSAM22: Explanation for soy-induced anaphylactic reactions and severe oral allergy syndrome (OAS) in birch pollen-allergic subjects

Author

Kleine-Tebbe, Jörg, primary, Martin, Anna, additional, Wangorsch, Andrea, additional, Crowell, Dring N, additional, Haustein, Uwe-Frithjof, additional, and Vieths, Stefan, additional

Published
2002
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18. Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma.

Author

Noga O, Hanf G, Brachmann I, Klucken AC, Kleine-Tebbe J, Rosseau S, Kunkel G, Suttorp N, and Seybold J

Subjects
Adult, Aged, Antibodies, Anti-Idiotypic, Antibodies, Monoclonal, Humanized, Apoptosis drug effects, Apoptosis immunology, Asthma pathology, Cytokines metabolism, Eosinophils immunology, Eosinophils pathology, Female, Humans, Male, Middle Aged, Omalizumab, T-Lymphocytes metabolism, Allergens immunology, Anti-Asthmatic Agents pharmacology, Antibodies, Monoclonal pharmacology, Asthma drug therapy, Asthma immunology, Eosinophils drug effects, T-Lymphocytes drug effects, T-Lymphocytes immunology
Abstract

Background: Omalizumab is a recombinant monoclonal anti-IgE antibody with proven efficacy in allergic diseases and further anti-inflammatory potency in the treatment of asthma., Objectives: To explore the anti-inflammatory mechanism of omalizumab, we investigated the induction of immunologic changes leading to eosinophil apoptosis and examined T-lymphocyte cytokine profiles in patients with allergic asthma., Methods: Nineteen patients with allergic asthma were enrolled and received omalizumab at a dose of at least 0.016 mg/kg/IgE (IU/mL) every 4 weeks. Peripheral eosinophils and T-lymphocyte cytokine profiles were evaluated by fluorescence-activated cell sorting before treatment (baseline), at 12 weeks of treatment, and 12 weeks after discontinuation of treatment with omalizumab or placebo., Results: Markers of eosinophil apoptosis (Annexin V) were significantly increased in omalizumab recipients compared with placebo, whereas no changes in markers of necrosis (7-amino-actinomycin) or eosinophil activation CD69 or Fas receptor (CD95) were detected. GM-CSF+ lymphocytes were reduced in omalizumab recipients compared with placebo. Fewer IL-2+ and IL-13+ lymphocytes were evident in omalizumab recipients than in the placebo group. There were no significant differences in IL-5, IFN-gamma, or TNF-alpha between the omalizumab and placebo groups., Conclusion: These findings provide further evidence that omalizumab has additional anti-inflammatory activity demonstrated by induction of eosinophil apoptosis and downregulation of the inflammatory cytokines IL-2 and IL-13. Further studies are needed to determine the underlying mechanisms., Clinical Implications: These findings support the critical role of IgE in the regulation of inflammation in allergic asthma: influencing the inflammation is the key to control the more severe type of asthma.

Published
2006
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19. Bites of the European pigeon tick (Argas reflexus): Risk of IgE-mediated sensitizations and anaphylactic reactions.

Author

Kleine-Tebbe J, Heinatz A, Gräser I, Dautel H, Hansen GN, Kespohl S, Rihs HP, Raulf-Heimsoth M, Vater G, Rytter M, and Haustein UF

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Allergens immunology, Animals, Child, Female, Humans, Male, Middle Aged, Risk Factors, Skin Tests, Anaphylaxis etiology, Argas immunology, Bites and Stings immunology, Columbidae parasitology, Immunoglobulin E immunology
Abstract

Background: Local and systemic reactions can occur after bites of Argas reflexus (Argas), a soft tick parasitizing pigeons., Objective: Risk assessment of IgE-mediated sensitizations and systemic reactions after Argas bites., Methods: Case histories, skin prick tests (SPTs) with a whole-body extract of Argas containing major allergen Arg r 1, and common inhalants and specific IgE measurements were obtained from 148 subjects who had had Argas bites and 20 volunteers as a control group., Results: Systemic reactions (urticaria, angioedema, dyspnea, cardiovascular dysregulation, unconsciousness) were reported in 12 of 148 (8%); 146 of 148 (99%) had local reactions. Atopy was found in 37 of 146 (25%) with local reactions and 3 of 12 (25%) with systemic reactions. SPT to Argas was positive in 24 of 148 (16%) with a high proportion of atopics 10 of 24 (42%); specific IgE to Argas was detectable in 12 of 135 (8% of 148) with moderate concordance to systemic reactions. No positive SPT or specific IgE results to Argas were obtained in the control group. Immunoblotting of 23 sera revealed an IgE-binding protein in 19 of 23 sera (82%) at 22 kd, indicating a major allergen of Argas., Conclusion: Severe anaphylactic reactions were infrequently (approximately 8%) found after bites of the soft tick Argas reflexus. Atopy is a risk factor for skin sensitizations to Argas, but not for systemic reactions after bites by Argas. Using a whole-body extract of Argas, diagnosis through SPT and specific IgE is hampered by false-negative and irrelevant positive results, particularly in atopy.

Published
2006
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