18 results on '"Wang, De Yun"'
Search Results
2. Expansion of a double-negative (CD27-IgD-) B cell population in the sputum of severe eosinophilic asthmatic patients
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Tan, Nadia Suray, primary, Mukherjee, Manali, additional, Lim, Hui Fang, additional, Angeli, Veronique, additional, Nair, Parameswaran, additional, Lim, Sheau Yng, additional, Rouers, Angeline, additional, Hwang, You Yi, additional, Thiam, Chung Hwee, additional, Tan, W.S. Daniel, additional, Liao, Wupeng, additional, Wong, W.S. Fred, additional, Liew, Mei Fong, additional, Larbi, Anis, additional, Fink, Katja, additional, and Wang, De Yun, additional
- Published
- 2022
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3. Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps
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Wang, Hai, primary, Hu, Dan-Qing, additional, Xiao, Qiao, additional, Liu, Yi-Bo, additional, Song, Jia, additional, Liang, Yuxia, additional, Ruan, Jian-Wen, additional, Wang, Zhe-Zheng, additional, Li, Jing-Xian, additional, Pan, Li, additional, Wang, Meng-Chen, additional, Zeng, Ming, additional, Shi, Li-Li, additional, Xu, Kai, additional, Ning, Qin, additional, Zhen, Guohua, additional, Yu, Di, additional, Wang, De-Yun, additional, Wenzel, Sally E., additional, and Liu, Zheng, additional
- Published
- 2021
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4. Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells
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Andiappan, Anand Kumar, primary, Puan, Kia Joo, additional, Lee, Bernett, additional, Yeow, Poh Tuang, additional, Yusof, Nurhashikin, additional, Merid, Simon Kebede, additional, Kumar, Dilip, additional, Lum, Josephine, additional, Foo, Shihui, additional, Koh, Geraldine, additional, Poidinger, Michael, additional, Zolezzi, Francesca, additional, Wang, De Yun, additional, Melén, Erik, additional, and Rotzschke, Olaf, additional
- Published
- 2021
- Full Text
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5. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
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Bousquet, Jean, primary, Hellings, Peter W., additional, Agache, Ioana, additional, Amat, Flore, additional, Annesi-Maesano, Isabella, additional, Ansotegui, Ignacio J., additional, Anto, Josep M., additional, Bachert, Claus, additional, Bateman, Eric D., additional, Bedbrook, Anna, additional, Bennoor, Kazi, additional, Bewick, Mickael, additional, Bindslev-Jensen, Carsten, additional, Bosnic-Anticevich, Sinthia, additional, Bosse, Isabelle, additional, Brozek, Jan, additional, Brussino, Luisa, additional, Canonica, Giorgio W., additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cepeda Sarabia, Alfonso M., additional, Chavannes, Niels H., additional, Cecchi, Lorenzo, additional, Correia de Sousa, Jaime, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Czarlewski, Wienczyslawa, additional, De Carlo, Giuseppe, additional, De Feo, Giulia, additional, Demoly, Pascal, additional, Devillier, Philippe, additional, Dykewicz, Mark S., additional, El-Gamal, Yehia, additional, Eller, Esben E., additional, Fonseca, Joao A., additional, Fontaine, Jean-François, additional, Fokkens, Wytske J., additional, Guzmán, Maria-Antonieta, additional, Haahtela, Tari, additional, Illario, Maddalena, additional, Ivancevich, Juan-Carlos, additional, Just, Jocelyne, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Kalayci, Omer, additional, Keil, Thomas, additional, Klimek, Ludger, additional, Kowalski, Marek L., additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas-Linnemann, Desiree, additional, Laune, Daniel, additional, Le, Lan T.T., additional, Carlsen, Karin Lodrup, additional, Lourenço, Olga, additional, Mahboub, Bassam, additional, Mair, Alpana, additional, Menditto, Enrica, additional, Milenkovic, Branislava, additional, Morais-Almeida, Mario, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, Murray, Ruth, additional, Naclerio, Robert, additional, Namazova-Baranova, Leyla, additional, Novellino, Ettore, additional, O'Hehir, Robyn E., additional, Ohta, Ken, additional, Okamoto, Yoshitaka, additional, Okubo, Kimi, additional, Onorato, Gabrielle L., additional, Palkonen, Susanna, additional, Panzner, Petr, additional, Papadopoulos, Nikos G., additional, Park, Hae-Sim, additional, Paulino, Ema, additional, Pawankar, Ruby, additional, Pfaar, Oliver, additional, Plavec, Davor, additional, Popov, Ted A., additional, Potter, Paul, additional, Prokopakis, Emmanuel P., additional, Rottem, Menachem, additional, Ryan, Dermot, additional, Salimäki, Johanna, additional, Samolinski, Boleslaw, additional, Sanchez-Borges, Mario, additional, Schunemann, Holger J., additional, Sheikh, Aziz, additional, Sisul, Juan-Carlos, additional, Rajabian-Söderlund, Rojin, additional, Sooronbaev, Talant, additional, Stellato, Cristiana, additional, To, Teresa, additional, Todo-Bom, Ana-Maria, additional, Tomazic, Peter-Valentin, additional, Toppila-Salmi, Sanna, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Ventura, Maria-Teresa, additional, Wagenmann, Martin, additional, Wang, De Yun, additional, Wallace, Dana, additional, Waserman, Susan, additional, Wickman, Magnus, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Zhong, Nanshan, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, Bousquet, J., additional, Hellings, P.W., additional, Aberer, W., additional, Agache, I., additional, Akdis, C.A., additional, Akdis, M., additional, Alberti, M.R., additional, Almeida, R., additional, Amat, F., additional, Angles, R., additional, Annesi-Maesano, I., additional, Ansotegui, I.J., additional, Anto, J.M., additional, Arnavielle, S., additional, Asayag, E., additional, Asarnoj, A., additional, Arshad, H., additional, Avolio, F., additional, Bacci, E., additional, Bachert, C., additional, Baiardini, I., additional, Barbara, C., additional, Barbagallo, M., additional, Baroni, I., additional, Barreto, B.A., additional, Basagana, X., additional, Bateman, E.D., additional, Bedolla-Barajas, M., additional, Bedbrook, A., additional, Bewick, M., additional, Beghé, B., additional, Bel, E.H., additional, Bergmann, K.C., additional, Bennoor, K.S., additional, Benson, M., additional, Bertorello, L., additional, Białoszewski, A.Z., additional, Bieber, T., additional, Bialek, S., additional, Bindslev-Jensen, C., additional, Bjermer, L., additional, Blain, H., additional, Blasi, F., additional, Blua, A., additional, Bochenska Marciniak, M., additional, Bogus-Buczynska, I., additional, Boner, A.L., additional, Bonini, M., additional, Bonini, S., additional, Bosnic-Anticevich, C.S., additional, Bosse, I., additional, Bouchard, J., additional, Boulet, L.P., additional, Bourret, R., additional, Bousquet, P.J., additional, Braido, F., additional, Briedis, V., additional, Brightling, C.E., additional, Brozek, J., additional, Bucca, C., additional, Buhl, R., additional, Buonaiuto, R., additional, Panaitescu, C., additional, Burguete Cabañas, M.T., additional, Burte, E., additional, Bush, A., additional, Caballero-Fonseca, F., additional, Caillot, D., additional, Caimmi, D., additional, Calderon, M.A., additional, Camargos, P.A.M., additional, Camuzat, T., additional, Canfora, G., additional, Canonica, G.W., additional, Cardona, V., additional, Carlsen, K.H., additional, Carreiro-Martins, P., additional, Carriazo, A.M., additional, Carr, W., additional, Cartier, C., additional, Casale, T., additional, Castellano, G., additional, Cecchi, L., additional, Cepeda Sarabia, A.M., additional, Chavannes, N.H., additional, Chen, Y., additional, Chiron, R., additional, Chivato, T., additional, Chkhartishvili, E., additional, Chuchalin, A.G., additional, Chung, K.F., additional, Ciaravolo, M.M., additional, Ciceran, A., additional, Cingi, C., additional, Ciprandi, G., additional, Carvalho Coehlo, A.C., additional, Colas, L., additional, Colgan, E., additional, Coll, J., additional, Conforti, D., additional, Correia de Sousa, J., additional, Cortés-Grimaldo, R.M., additional, Corti, F., additional, Costa, E., additional, Costa-Dominguez, M.C., additional, Courbis, A.L., additional, Cox, L., additional, Crescenzo, M., additional, Cruz, A.A., additional, Custovic, A., additional, Czarlewski, W., additional, Dahlen, S.E., additional, Dario, C., additional, da Silva, J., additional, Dauvilliers, Y., additional, Darsow, U., additional, De Blay, F., additional, De Carlo, G., additional, Dedeu, T., additional, de Fátima Emerson, M., additional, De Feo, G., additional, De Vries, G., additional, De Martino, B., additional, de Paula Motta Rubini, N., additional, Deleanu, D., additional, Demoly, P., additional, Denburg, J.A., additional, Devillier, P., additional, Di Capua Ercolano, S., additional, Di Carluccio, N., additional, Didier, A., additional, Dokic, D., additional, Dominguez-Silva, M.G., additional, Douagui, H., additional, Dray, G., additional, Dubakiene, R., additional, Durham, S.R., additional, Du Toit, G., additional, Dykewicz, M.S., additional, El-Gamal, Y., additional, Eklund, P., additional, Eller, E., additional, Emuzyte, R., additional, Farrell, J., additional, Farsi, A., additional, Ferreira de Mello, J., additional, Ferrero, J., additional, Fink-Wagner, A., additional, Fiocchi, A., additional, Fokkens, W.J., additional, Fonseca, J.A., additional, Fontaine, J.F., additional, Forti, S., additional, Fuentes-Perez, J.M., additional, Gálvez-Romero, J.L., additional, Gamkrelidze, A., additional, Garcia-Aymerich, J., additional, García-Cobas, C.Y., additional, Garcia-Cruz, M.H., additional, Gemicioğlu, B., additional, Genova, S., additional, George, C., additional, Gereda, J.E., additional, Gerth van Wijk, R., additional, Gomez, R.M., additional, Gómez-Vera, J., additional, González Diaz, S., additional, Gotua, M., additional, Grisle, I., additional, Guidacci, M., additional, Guldemond, N.A., additional, Gutter, Z., additional, Guzmán, M.A., additional, Haahtela, T., additional, Hajjam, J., additional, Hernández, L., additional, Hourihane, J.O.'B., additional, Huerta-Villalobos, Y.R., additional, Humbert, M., additional, Iaccarino, G., additional, Illario, M., additional, Ivancevich, J.C., additional, Jares, E.J., additional, Jassem, E., additional, Johnston, S.L., additional, Joos, G., additional, Jung, K.S., additional, Jutel, M., additional, Kaidashev, I., additional, Kalayci, O., additional, Kalyoncu, A.F., additional, Karjalainen, J., additional, Kardas, P., additional, Keil, T., additional, Keith, P.K., additional, Khaitov, M., additional, Khaltaev, N., additional, Kleine-Tebbe, J., additional, Klimek, L., additional, Kowalski, M.L., additional, Kuitunen, M., additional, Kull, I., additional, Kuna, P., additional, Kupczyk, M., additional, Kvedariene, V., additional, Krzych-Fałta, E., additional, Lacwik, P., additional, Larenas-Linnemann, D., additional, Laune, D., additional, Lauri, D., additional, Lavrut, J., additional, Le, L.T.T., additional, Lessa, M., additional, Levato, G., additional, Li, J., additional, Lieberman, P., additional, Lipiec, A., additional, Lipworth, B., additional, Lodrup Carlsen, K.C., additional, Louis, R., additional, Lourenço, O., additional, Luna-Pech, J.A., additional, Maciej, K., additional, Magnan, A., additional, Mahboub, B., additional, Maier, D., additional, Mair, A., additional, Majer, I., additional, Malva, J., additional, Mandajieva, E., additional, Manning, P., additional, De Manuel Keenoy, E., additional, Marshall, G.D., additional, Masjedi, M.R., additional, Maspero, J.F., additional, Mathieu-Dupas, E., additional, Matta Campos, J.J., additional, Matos, A.L., additional, Maurer, M., additional, Mavale-Manuel, S., additional, Mayora, O., additional, Medina-Avalos, M.A., additional, Melén, E., additional, Melo-Gomes, E., additional, Meltzer, E.O., additional, Menditto, E., additional, Mercier, J., additional, Miculinic, N., additional, Mihaltan, F., additional, Milenkovic, B., additional, Moda, G., additional, Mogica-Martinez, M.D., additional, Mohammad, Y., additional, Momas, I., additional, Montefort, S., additional, Monti, R., additional, Mora Bogado, D., additional, Morais-Almeida, M., additional, Morato-Castro, F.F., additional, Mösges, R., additional, Mota-Pinto, A., additional, Moura Santo, P., additional, Mullol, J., additional, Münter, L., additional, Muraro, A., additional, Murray, R., additional, Naclerio, R., additional, Nadif, R., additional, Nalin, M., additional, Napoli, L., additional, Namazova-Baranova, L., additional, Neffen, H., additional, Niedeberger, V., additional, Nekam, K., additional, Neou, A., additional, Nieto, A., additional, Nogueira-Silva, L., additional, Nogues, M., additional, Novellino, E., additional, Nyembue, T.D., additional, O'Hehir, R.E., additional, Odzhakova, C., additional, Ohta, K., additional, Okamoto, Y., additional, Okubo, K., additional, Onorato, G.L., additional, Ortega Cisneros, M., additional, Ouedraogo, S., additional, Pali-Schöll, I., additional, Palkonen, S., additional, Panzner, P., additional, Papadopoulos, N.G., additional, Park, H.S., additional, Papi, A., additional, Passalacqua, G., additional, Paulino, E., additional, Pawankar, R., additional, Pedersen, S., additional, Pépin, J.L., additional, Pereira, A.M., additional, Persico, M., additional, Pfaar, O., additional, Phillips, J., additional, Picard, R., additional, Pigearias, B., additional, Pin, I., additional, Pitsios, C., additional, Plavec, D., additional, Pohl, W., additional, Popov, T.A., additional, Portejoie, F., additional, Potter, P., additional, Pozzi, A.C., additional, Price, D., additional, Prokopakis, E.P., additional, Puy, R., additional, Pugin, B., additional, Pulido Ross, R.E., additional, Przemecka, M., additional, Rabe, K.F., additional, Raciborski, F., additional, Rajabian-Soderlund, R., additional, Reitsma, S., additional, Ribeirinho, I., additional, Rimmer, J., additional, Rivero-Yeverino, D., additional, Rizzo, J.A., additional, Rizzo, M.C., additional, Robalo-Cordeiro, C., additional, Rodenas, F., additional, Rodo, X., additional, Rodriguez Gonzalez, M., additional, Rodriguez-Mañas, L., additional, Rolland, C., additional, Rodrigues Valle, S., additional, Roman Rodriguez, M., additional, Romano, A., additional, Rodriguez-Zagal, E., additional, Rolla, G., additional, Roller-Wirnsberger, R.E., additional, Romano, M., additional, Rosado-Pinto, J., additional, Rosario, N., additional, Rottem, M., additional, Ryan, D., additional, Sagara, H., additional, Salimäki, J., additional, Samolinski, B., additional, Sanchez-Borges, M., additional, Sastre-Dominguez, J., additional, Scadding, G.K., additional, Schunemann, H.J., additional, Scichilone, N., additional, Schmid-Grendelmeier, P., additional, Serpa, F.S., additional, Shamai, S., additional, Sheikh, A., additional, Sierra, M., additional, Simons, F.E.R., additional, Siroux, V., additional, Sisul, J.C., additional, Skrindo, I., additional, Solé, D., additional, Somekh, D., additional, Sondermann, M., additional, Sooronbaev, T., additional, Sova, M., additional, Sorensen, M., additional, Sorlini, M., additional, Spranger, O., additional, Stellato, C., additional, Stelmach, R., additional, Stukas, R., additional, Sunyer, J., additional, Strozek, J., additional, Szylling, A., additional, Tebyriçá, J.N., additional, Thibaudon, M., additional, To, T., additional, Todo-Bom, A., additional, Tomazic, P.V., additional, Toppila-Salmi, S., additional, Trama, U., additional, Triggiani, M., additional, Suppli Ulrik, C., additional, Urrutia-Pereira, M., additional, Valenta, R., additional, Valero, A., additional, Valiulis, A., additional, Valovirta, E., additional, van Eerd, M., additional, van Ganse, E., additional, van Hague, M., additional, Vandenplas, O., additional, Ventura, M.T., additional, Vezzani, G., additional, Vasankari, T., additional, Vatrella, A., additional, Verissimo, M.T., additional, Viart, F., additional, Viegi, M., additional, Vicheva, D., additional, Vontetsianos, T., additional, Wagenmann, M., additional, Walker, S., additional, Wallace, D., additional, Wang, D.Y., additional, Waserman, S., additional, Werfel, T., additional, Westman, M., additional, Wickman, M., additional, Williams, D.M., additional, Williams, S., additional, Wilson, N., additional, Wright, J., additional, Wroczynski, P., additional, Yakovliev, P., additional, Yawn, B.P., additional, Yiallouros, P.K., additional, Yorgancioglu, A., additional, Yusuf, O.M., additional, Zar, H.J., additional, Zhang, L., additional, Zhong, N., additional, Zernotti, M.E., additional, Zidarn, M., additional, Zuberbier, T., additional, Zubrinich, C., additional, and Zurkuhlen, A., additional
- Published
- 2019
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6. CD151, a novel host factor of nuclear export signaling in influenza virus infection
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Qiao, Yongkang, primary, Yan, Yan, additional, Tan, Kai Sen, additional, Tan, Sheryl S.L., additional, Seet, Ju Ee, additional, Arumugam, Thiruma Valavan, additional, Chow, Vincent T.K., additional, Wang, De Yun, additional, and Tran, Thai, additional
- Published
- 2018
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7. Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis
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Andiappan, Anand Kumar, primary, Sio, Yang Yie, additional, Lee, Bernett, additional, Suri, Bani Kaur, additional, Matta, Sri Anusha, additional, Lum, Josephine, additional, Foo, Shihui, additional, Koh, Geraldine, additional, Liu, Jianjun, additional, Zolezzi, Francesca, additional, Poidinger, Michael, additional, Wang, De Yun, additional, Rotzschke, Olaf, additional, and Chew, Fook Tim, additional
- Published
- 2016
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8. A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis
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Jin, Peng, primary, Andiappan, Anand Kumar, additional, Quek, Jia Min, additional, Lee, Bernett, additional, Au, Bijin, additional, Sio, Yang Yie, additional, Irwanto, Astrid, additional, Schurmann, Claudia, additional, Grabe, Hans Jörgen, additional, Suri, Bani Kaur, additional, Matta, Sri Anusha, additional, Westra, Harm-Jan, additional, Franke, Lude, additional, Esko, Tonu, additional, Sun, Liangdan, additional, Zhang, Xuejun, additional, Liu, Hong, additional, Zhang, Furen, additional, Larbi, Anis, additional, Xu, Xin, additional, Poidinger, Michael, additional, Liu, Jianjun, additional, Chew, Fook Tim, additional, Rotzschke, Olaf, additional, Shi, Li, additional, and Wang, De Yun, additional
- Published
- 2015
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9. Genetic variants of inducible costimulator are associated with allergic asthma susceptibility
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Andiappan, Anand Kumar, primary, Narayanan, Sriram, additional, Myers, Rachel A., additional, Lee, Bernett, additional, Nieuwenhuis, Maartje A., additional, Nardin, Alessandra, additional, Park, Choon-Sik, additional, Shin, Hyoung Doo, additional, Kim, Jeong-Hyun, additional, Westra, Harm-Jan, additional, Franke, Lude, additional, Esko, Tonu, additional, Metspalu, Andres, additional, Teo, Yik-Ying, additional, Saw, Seang Mei, additional, Khor, Chiea Chuen, additional, Liu, Jianjun, additional, Koppelman, Gerard H., additional, Postma, Dirkje S., additional, Poidinger, Michael, additional, Connolly, John E., additional, Wang, De Yun, additional, Rotzschke, Olaf, additional, Curotto de Lafaille, Maria A., additional, and Chew, Fook Tim, additional
- Published
- 2015
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10. Impairment of cilia architecture and ciliogenesis in hyperplastic nasal epithelium from nasal polyps
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Li, Ying Ying, primary, Li, Chun Wei, additional, Chao, Siew Shuen, additional, Yu, Feng Gang, additional, Yu, Xue Min, additional, Liu, Jing, additional, Yan, Yan, additional, Shen, Liang, additional, Gordon, William, additional, Shi, Li, additional, and Wang, De Yun, additional
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- 2014
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11. Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in Singapore
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Andiappan, Anand Kumar, primary, Wang, De Yun, additional, Anantharaman, Ramani, additional, Suri, Bani Kaur, additional, Lee, Bernett Teck Kwong, additional, Rotzschke, Olaf, additional, Liu, Jianjun, additional, and Chew, Fook Tim, additional
- Published
- 2013
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12. Role of p63/p73 in epithelial remodeling and their response to steroid treatment in nasal polyposis
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Li, Chun Wei, primary, Shi, Li, additional, Zhang, Ke Ke, additional, Li, Tian Ying, additional, Lin, Zhi Bin, additional, Lim, Mei Kee, additional, McKeon, Frank, additional, Xian, Wa, additional, and Wang, De Yun, additional
- Published
- 2011
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13. Reply
- Author
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Cao, Ping-Ping, primary, Li, Hua-Bin, additional, Wang, De-Yun, additional, Desrosiers, Martin, additional, and Liu, Zheng, additional
- Published
- 2010
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14. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese
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Cao, Ping-Ping, primary, Li, Hua-Bin, additional, Wang, Bao-Feng, additional, Wang, Shui-Bin, additional, You, Xue-Jun, additional, Cui, Yong-Hua, additional, Wang, De-Yun, additional, Desrosiers, Martin, additional, and Liu, Zheng, additional
- Published
- 2009
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15. Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21
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Gao, Yun Feng, primary, Wang, De Yun, additional, Ong, Tan Ching, additional, Tay, Su Ling, additional, Yap, Kwong Hsia, additional, and Chew, Fook Tim, additional
- Published
- 2007
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16. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- Author
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Karin C. Lødrup Carlsen, L. Cecchi, F. Portejoie, T. Vontetsianos, Olivier Vandenplas, M. van Hague, D. Mora Bogado, M. Illario, Dana Wallace, L. Namazova-Baranova, E. Asayag, I. Ribeirinho, E. Costa, Shona Pedersen, Inger Kull, Davor Plavec, M. Morais-Almeida, Mickael Bewick, N.H. Chavannes, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, Faradiba Sarquis Serpa, S. Arnavielle, F. Corti, Moises A. Calderon, Martín Bedolla-Barajas, Mette Sørensen, Isabella Annesi-Maesano, Elaine Colgan, Przemyslaw Kardas, M. van Eerd, Jorge Maspero, Valérie Siroux, Isabelle Momas, Ralph Mösges, Yves Dauvilliers, T. Keil, T. Bieber, Marit Westman, Rachel Nadif, O. Pfaar, A.C. Carvalho Coehlo, R. M. Cortés-Grimaldo, I. Skrindo, Piotr Kuna, Nicola Scichilone, Antonella Muraro, Kimihiro Okubo, Paulo Augusto Moreira Camargos, C. Cartier, Oliver Pfaar, K. Ohta, Barbara P. Yawn, Igor Kaidashev, Michel Thibaudon, X. Basagana, I. Kaidashev, Bilun Gemicioglu, S. Genova, Hae-Sim Park, J.J. Matta Campos, Simon Walker, Ulf Darsow, Fulvio Braido, J. Salimäki, T. Zuberbier, Raphaël Chiron, Mohammad Reza Masjedi, G.D. Marshall, Branislava Milenkovic, W. J. Fokkens, Eric D. Bateman, Robert M. Naclerio, Steve Montefort, M. de Fátima Emerson, T. Werfel, Cemal Cingi, A. Szylling, Martin Wagenmann, I. Baiardini, L. T. T. Le, N. Khaltaev, Ki-Suck Jung, Agnieszka Lipiec, Panayiotis K. Yiallouros, A Valero, R. Gerth van Wijk, L. Hernández, Marek L. Kowalski, C. Zubrinich, Sinthia Bosnic-Anticevich, Miguel A. Sierra, Erik Melén, T. Haahtela, Rute Almeida, Violeta Kvedariene, R. Pawankar, T.A. Popov, Flore Amat, Sanna Toppila-Salmi, M. Gotua, A. Sheikh, A. Bedbrook, Torsten Zuberbier, B. De Martino, Gérard Dray, Francesca Avolio, E. Mandajieva, B. Samolinski, Petr Panzner, P. Kuna, Philippe-Jean Bousquet, T. D. Nyembue, Luo Zhang, Leyla Namazova-Baranova, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, M. Bochenska Marciniak, Cristiana Stellato, J. da Silva, J. E. Gereda, Han-Jung Park, M.C. Costa-Dominguez, W. Carr, Dirceu Solé, S. Forti, Nanshan Zhong, Jordi Sunyer, Alain Didier, Y. Z. Chen, Thomas B. Casale, Jim Phillips, Isabelle Bosse, Manuel Teixeira Veríssimo, D. Y. Wang, U. Trama, Cristina Bárbara, David Somekh, T. Camuzat, R. N. Naclerio, Enrico Novellino, Leszek Klimek, M. Rodriguez Gonzalez, Holger J. Schünemann, Mario Barbagallo, D. Larenas-Linnemann, Mario Sánchez-Borges, Massimo Triggiani, Y. Okamoto, E. Mathieu-Dupas, N. Di Carluccio, S. Toppila-Salmi, Omer Kalayci, Rudolf Valenta, J. Coll, F. de Blay, Wienczyslawa Czarlewski, W. Pohl, Piotr Wroczyński, Kian Fan Chung, Nikolaos G. Papadopoulos, Pascal Demoly, Hubert Blain, M. Crescenzo, O. Kalayci, Leocadio Rodríguez-Mañas, G. Moda, L. Cox, Z. Gutter, A. Mair, Andrew Bush, Maria-Dolores Mogica-Martinez, Giorgio Walter Canonica, Antonio Valero, Daniel Laune, A. Zurkuhlen, Paul C. Potter, D. Wallace, Gabrielle L. Onorato, Mihaela Zidarn, E.P. Prokopakis, Anne Lise Courbis, Sergio Bonini, Ruta Dubakiene, A. Papi, Y. El-Gamal, Jacques Mercier, Wytske Fokkens, Rodolphe Bourret, S. Palkonen, A. Yorgancioglu, G. Vezzani, J. A. Rizzo, D. Plavec, D. Caillot, G. De Feo, E. Menditto, Caterina Bucca, A. C. Pozzi, Hironori Sagara, I. Grisle, I. Pin, Christopher E. Brightling, Ludger Klimek, F.F. Morato-Castro, Désirée Larenas-Linnemann, Alessandro Vatrella, A. A. Cruz, Guy Joos, E.D. Bateman, Erendira Rodriguez-Zagal, H. Douagui, T. To, Edgardo Jares, C. Bindslev-Jensen, G. Levato, J. O. B. Hourihane, R. Rajabian-Soderlund, C. Odzhakova, J. Bousquet, M. T. Ventura, Arzu Yorgancioglu, Osman M. Yusuf, H. J. Zar, Giovanni Rolla, Sebastian L. Johnston, M.S. Dykewicz, Esben Eller, A. Gamkrelidze, Filip Raciborski, Renzo Angles, Rafael Stelmach, M. Nogues, David Price, Mário Morais-Almeida, Tari Haahtela, Teresa To, D. Conforti, Stephen R. Durham, S. Gonzalez Diaz, V. Cardona, Werner Aberer, B. Milenkovic, Luigi Napoli, K. C. 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Alberti, Jean-Louis Pépin, Kimi Okubo, Juan Carlos Ivancevich, Patrik Eklund, Benoit Pugin, C. Dario, Mussa Khaitov, Luisa Brussino, A.G. Chuchalin, Elísio Costa, Susanna Palkonen, Lars Münter, Pedro Carreiro-Martins, R.E. Pulido Ross, Ettore Novellino, Kai-Håkon Carlsen, María Antonieta Guzmán, G.W. Canonica, Gabriel Onorato, Giuseppe De Carlo, R.E. Roller-Wirnsberger, Brian J. Lipworth, M. A. Guzman, J.N. Tebyriçá, Adnan Custovic, Yoshitaka Okamoto, Rimantas Stukas, P. Manning, J. Sastre-Dominguez, Caroline L.S. George, Robyn E O'Hehir, K. Maciej, Bassam Mahboub, J. F. Fontaine, Arũnas Valiulis, Xavier Rodó, D. Vicheva, G. Canfora, Vitalis Briedis, S. Rodrigues Valle, Mark S. Dykewicz, Joanne Rimmer, G. Castellano, B. Pigearias, A. L. Boner, Yunuen Rocío Huerta-Villalobos, Christine Rolland, H. Neffen, H. Arshad, Javier Gómez-Vera, P. Moura Santo, Frederic Viart, F. Blasi, J. Garcia-Aymerich, Lorenzo Cecchi, V. Niedeberger, Giorgio Ciprandi, F. 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Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Hajjam J., Hernandez L., Hourihane J.O., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kalyoncu A.F., Karjalainen J., Kardas P., Keith P.K., Khaltaev N., Kleine-Tebbe J., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Maier D., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta 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M., Bachert, Clau, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thoma, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-Françoi, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlo, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thoma, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T. T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlo, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Aruna, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnu, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Alberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W. J., Fonseca, J. A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Gálvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioğlu, B., Genova, S., George, C., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J. O. 'B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J. C., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenço, O., Luna-Pech, J. A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melén, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J. N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratory of clinical immunology, Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia [Bilbao], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], Department of Dermatology [Graz, Austria], Medical University Graz, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Ghent University Hospital, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), IMIM-Hospital del Mar, Generalitat de Catalunya, University of Cape Town, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Centre de gérontologie, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Université Laval [Québec] (ULaval), Departments of Clinical Epidemiology and Biostatistics and Medicine [Ontario], Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Royal Brompton Hospital, Région Languedoc-Roussillon-Midi-Pyrénées, Vall d'Hebron University Hospital [Barcelona], University of South Florida [Tampa] (USF), Università degli Studi di Firenze = University of Florence (UniFI), University of Michigan, Department of Atmospheric, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Russian State Medical University, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), UCB Pharma, Colombes, Hôpital Gui de Chauliac [CHU Montpellier], CHU Strasbourg, European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Università degli Studi di Salerno = University of Salerno (UNISA), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Linköping University (LIU), Department of Dermatology and Allergy Centre, Odense University Hospital, Vilnius University [Vilnius], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Swedish Meteorological and Hydrological Institute (SMHI), CORYSS-TESS, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Biologie des organismes marins et écosystèmes (BOME), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), NRC Institute of immunology FMBA, Moscow Russian federation, Allergy and Asthma Center Westend, German Society for Otorhinolaryngology HNS, Rheinische Friedrich-Wilhelms-Universität Bonn, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Medical University of Łódź (MUL), Hospital Medica Sur, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Applied Physical Chemistry Laboratory (APCLab), Institute of Geophysics and Planetary Physics [Los Angeles] (IGPP), University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Institute of Oceanology [China], University of Beira Interior [Portugal] (UBI), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), 'Federico II' University of Naples Medical School, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Allergy and Clinical Immunology Department, Hospital CUF Descobertas, Universität zu Köln = University of Cologne, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Department of Pharmacy Naples, Université de Naples, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Dept. of Electronic Engineering, Chubu University, Department of Otorhinolaryngology, Chiba University Hospital, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University, Allergy and Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe), Department of Pediatrics, Nippon Medical School, Centre Hospitalier Universitaire [Grenoble] (CHU), Department of Otorhinolaryngology, Head and Neck Surgery [Mannheim, Germany], University Hospital Mannheim, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Children’s Hospital Srebrnjak [Zagreb, Croatia], Department of Physics [UMIST Manchester], University of Manchester Institute of Science and Technology (UMIST), Laboratori Nazionali del Sud (LNS), Getafe University Hospital, Madrid, Karl-Franzens-Universität Graz, Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Allergy Asthma and Immunology [Haifa, Israel], Ha'Emek Medical Center, Afula-Rappaport Faculty of Medicine, University of Edinburgh, Medical University of Warsaw - Poland, Department of Allergy and Clinical Immunology [Caracas, Venezuela], Centro Médico Docente La Trinidad, Department of Computer Science [Haifa], University of Haifa [Haifa], Allergy and Respiratory Research Group, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, Réseau National de Surveillance Aérobiologique (RNSA), Berkeley Seismological Laboratory, Division of Clinical Immunology and Allergy, University of Naples Federico II = Università degli studi di Napoli Federico II, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Vilnius University Clinic of Children's Diseases, Suomen Terveystalo Allergy Clinic, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Nova Southeastern University (NSU), Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Sachs' Children's Hospital, IAES, Department of Pulmonology, Manisa Celal Bayar University, Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico] (CETI), The University of New Mexico [Albuquerque], National Key State Laboratory for ThermoStructural Composites (TSCM), Northwestern Polytechnical University [Xi'an] (NPU), Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, University Hospital of Cologne [Cologne], Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union)., European Project: 643803,H2020,H2020-HCO-2014,PROEIPAHA(2015), UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Quiròn Bizkaia Erandio, Université Pierre et Marie Curie - Paris 6 (UPMC), University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Salerno (UNISA), Institut de Physique du Globe de Paris (IPGP), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), University of California-University of California, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital CUF-Descobertas, Universität zu Köln, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Harvard University [Cambridge], University of Genoa (UNIGE), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Graz, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centro Medico-Docente La Trinidad, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Università degli studi di Napoli Federico II, Center for Evolutionary and theoretical Immunology, Biology, National Institute for Health Research, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität [Graz, Autriche], Department of Dermatology, Allergology and Venereology, Clinicum, University of Helsinki, Children's Hospital, Faculty of Law, HUS Children and Adolescents, HUS Inflammation Center, University Hospitals Leuven [Leuven], Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, University of Zürich [Zürich] (UZH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of South Florida (USF), Università degli Studi di Firenze = University of Florence [Firenze], Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto [Porto], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) (SONDRA), ONERA-CentraleSupélec-Université Paris Saclay (COmUE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), RNSA, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), National Institute for Nuclear Physics (INFN), Université Laval, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Università degli Studi di Firenze [Firenze], University of Salerno (UNISA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Universidade do Minho, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, uBibliorum, and Internal Medicine
- Subjects
Allergy ,Medicina Básica [Ciências Médicas] ,asthma -- guideline ,Allergic asthma ,DECISION-MAKING ,Allergic Rhinitis and Its Impact on Asthma ,GUIDELINES ,Medical and Health Sciences ,Medical Records ,0302 clinical medicine ,Health care ,Immunology and Allergy ,030212 general & internal medicine ,asthma ,Change management ,rhinitis ,Immunology ,MASK-RHINITIS ,ComputingMilieux_MISCELLANEOUS ,Rinitis ,mobilne aplikacije ,upravljanje sprememb ,Medical record ,GLOBAL STRATEGY ,WORK PRODUCTIVITY ,Telemedicine ,mobile applications ,3. Good health ,Asma alérgica ,rhiniti ,1107 Immunology ,Ciências Médicas::Medicina Básica ,klinične poti ,allergic -- guideline ,Life Sciences & Biomedicine ,Human ,PATIENT PARTICIPATION ,Allergic Rhinitis ,medicine.medical_specialty ,animal structures ,multimorbidity ,EUROPEAN INNOVATION PARTNERSHIP ,Change Management ,[object Object] ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Asthma/diagnosis ,CHRONIC DISEASES ,MACVIA-ARIA ,03 medical and health sciences ,medicine ,multimorbidnost ,QUALITY ,Humans ,critical pathways ,astma -- smernica ,Patient participation ,Asma ,udc:616.2 ,Asthma ,Science & Technology ,ARIA ,business.industry ,Multimorbidity ,Rhinitis, Allergic ,Settore MED/09 - MEDICINA INTERNA ,change management ,Mobile Airways Sentinel Network (MASK) Study Group ,Guideline ,ta3121 ,medicine.disease ,Rinite alérgica ,Rhinitis, Allergic/diagnosis ,Integrated care ,alergijski rinitis -- smernica ,Allergic Rhinitis and Its Impact on Asthma, asthma, Change management, rhinitis, Immunology and Allergy, Immunology ,030228 respiratory system ,Family medicine ,3121 General medicine, internal medicine and other clinical medicine ,Medical Record ,Clinical Medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Impact on Asthma - Abstract
Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional., EAACI -European Academy of Allergy and Clinical Immunology(undefined), info:eu-repo/semantics/acceptedVersion
- Published
- 2018
17. Hypoxia-inducible factor 1α activates the NLRP3 inflammasome to regulate epithelial differentiation in chronic rhinosinusitis.
- Author
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Zhong B, Sun S, Tan KS, Ong HH, Du J, Liu F, Liu Y, Liu S, Ba L, Li J, Wang Y, and Liu J
- Subjects
- Humans, Inflammasomes metabolism, NLR Family, Pyrin Domain-Containing 3 Protein genetics, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, HEK293 Cells, Inflammation pathology, Hypoxia, Rhinosinusitis, Sinusitis
- Abstract
Background: Chronic rhinosinusitis (CRS) is an upper airway inflammation disease associated with hypoxia-mediated inflammation. The effect of hypoxia-inducible factor 1α (HIF-1α) on NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation in the pathogenesis of sinonasal mucosa is unclear., Objective: We investigated the effect and mechanism of HIF-1α on NLRP3 inflammasome activation in the primary human nasal epithelial cells (hNECs)., Methods: We measured the expression levels of HIF-1α and the NLRP3 inflammasome in nasal biopsy samples and hNECs derived from negative controls (healthy) and patients with CRS with and without nasal polyps, then further analyzed the specific mechanism of HIF-1α regulation of the NLRP3 inflammasome and its effect on hNEC differentiation., Results: Increased mRNA and protein expression levels of HIF-1α and the NLRP3 inflammasome were found in all CRS biopsy samples. HIF-1α enhanced expression of phosphorylated NLRP3 (S295) in both HEK293T cells and hNECs; it also promoted recruitment of caspase-1 and apoptotic speck-like protein containing caspase recruitment domain (aka ASC) by NLRP3. HIF-1α also improved NLRP3's stability by preventing NLRP3 degradation caused by hypoxia-mediated inflammation. In addition, HIF-1α could also increase expression of Mucin5AC and decrease expression of α-tubulin by promoting activation of the NLRP3 inflammasome in hNECs. In addition, HIF-1α could also directly promote P63 expression in hNECs., Conclusion: HIF-1α could potentially induce cilia loss and enhance the proliferation of goblet cells, possibly mediated by the regulation of NLRP3 phosphorylation in CRS inflammation., (Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
18. Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro.
- Author
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Yan Y, Tan KS, Li C, Tran T, Chao SS, Sugrue RJ, Shi L, Chow VT, and Wang DY
- Subjects
- Cells, Cultured, Epithelial Cells pathology, Humans, Influenza, Human pathology, Nasal Mucosa pathology, Epithelial Cells virology, Influenza A Virus, H3N2 Subtype growth & development, Influenza, Human metabolism, Nasal Mucosa virology
- Published
- 2016
- Full Text
- View/download PDF
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