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A series of CuO/NiO nanoparticles with different Cu and Ni precursor concentrations represented as N12 (1:2), N22 (1:1) and N21 (2:1) (Cu2+:Ni2+) were produced by modified green solution combustion route using Moringa oleifera leaves extract as an organic fuel. The prepared CuO/NiO nanoparticles were analytically characterized using UV-Vis diffuse reflectance spectroscopy, X-ray diffractometry, X-ray photoelectron spectroscopy, Brunauer-Emmett-Teller analysis, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, and vibrating sample magnetometry. Morphological studies showed uniform and nearly monodisperse nanoparticles having average grain size of 34 nm for N22 nanoparticles while the N12 and N21 compositions showed uniform nanoparticles with the grain size of 12 nm and 22 nm respectively. The existence of CuO and NiO phases in nanoparticles was verified by XPS analysis. N12, N22 and N21 had band gaps in the range of 2.19–2.49 eV and specific surface area in the range of 4.92–11.2 m2/g. The susceptibility vs. temperature plots for mixed oxides nanoparticles showed distinct magnetic behaviour for different ratio. The coercivity and saturation magnetization reached a maximum value for N22 (130 Oe and 0.133 emu/g). These biogenic nanoparticles could be a strong choice for biological applications due to their soft magnetic behaviour and biocompatibility. [Display omitted] • CuO/NiO nanoparticles with varying ratio (1:2; 1:1 and 2:1) were prepared. • Green solution combustion (using Moringa extract) was adopted for the synthesis. • Optical, structural and magnetic properties were investigated. • VSM measurements exhibited a distinct magnetic character for each ratio. [ABSTRACT FROM AUTHOR]

The present study reports the synthesis and physico-chemical characterization of Mn 1−x Zn x Fe 2 O 4 (x = 0.5, 0.4, 0.3, 0.2, 0.1) nanoparticles-based magnetic fluids with reference to magnetic fluid hyperthermia. The properties of these fluids are studied using XRD, FTIR, TGA, VSM and the induction heating equipment operated at 330 kHz. The heating response of the fluids is investigated within the safety limit of H·f (4.8 *108 A/m-s). The study is also extended to simulate it for the agarose gel phantom system. The power absorption by these samples in distilled water and in agarose gel is calculated to compare with the experimentally observed value. To the best of the author's knowledge, no study of temperature sensitive magnetic fluid is reported on agarose gel, which simulates or phantom an in vivo condition. Results analysis show that the control of hyperthermia temperature is possible at lower fields and frequencies for the A91 sample with the smallest possible concentration, which can be acceptable for in vitro study. • The synthesis and physico-chemical characterization of Mn 1−x Zn x Fe 2 O 4 nanoparticles (x = 0.5, to 0.1) based magnetic fluids is reported. • The heating response of the fluids is investigated within the safety limit of H·f (4.8 *108 A/m-s). • The power absorption by these samples are calculated to compare with the experimentally observed value. • To the best of author's knowledge, study of temperature sensitive magnetic fluid in agarose gel is not reported yet. • Results show that the A91 sample controls hyperthermia temperature at lower field, frequency and lowest concentration. [ABSTRACT FROM AUTHOR]

This study presents a significant advancement in cancer therapy through the application of Mn-substituted magnetite superparamagnetic (SPM) nanoparticles, highlighting the potential of magnetic fluid hyperthermia (MFH) as an effective modality. However, its clinical applications have been limited by challenges such as low heating performance, agglomeration of magnetic nanoparticles (MNPs) in blood veins, and cytotoxicity. To address these crucial issues, surface engineered MNPs were synthesised by adopting a reverse micelles-based co-precipitation approach that effectively overcomes MNP agglomeration, ensuring uniform dispersion of the nanoparticles. Through careful optimization of Mn ion substitution within magnetite, we have achieved a significant enhancement in the heating performance of the magnetite SPM nanoparticles. The substitution of Mn2+ ions in magnetite has notably increased the specific absorption rate (SAR) value, as evidenced by a remarkable 181% increase (SAR: 510 kW/kg) obtained using the Box Lucas Method. This enhancement can be attributed to the elevated saturation magnetization resulting from the appropriate cation distribution within the MNPs. Furthermore, the increase in spin relaxation time with higher Mn concentration also contributes to the improvement in SAR values as MNPs retain their magnetic moments for an extended period before relaxing, leading to enhanced energy dissipation and higher SAR values. The hemolysis assays demonstrated minimal hemolysis rates (<5%) when exposed to red blood cells (RBCs), confirming the high biocompatibility of the MNPs. Additionally, MTT assays revealed excellent cytocompatibility (>90% cell viability) for Human Embryonic Kidney (HEK-293) cells across all compositions, further affirming the potential of these MNPs for clinical treatments. Overall, this study unveils a sustainable approach for cancer therapy using Mn-substituted magnetite SPM nanoparticles. Their remarkable heating performance and excellent biocompatibility make them promising for clinical applications in MFH. • Significant advancement in MFH for cancer treatment using Mn-substituted magnetite nanoparticles. • Achieved a remarkable 181% increase in specific absorption rate (SAR) for enhanced heating performance. • Overcame challenges of agglomeration through surface engineering and reverse micelles-based co-precipitation. • MNPs demonstrated high biocompatibility with minimal hemolysis rates and excellent cytocompatibility for HEK-293 cells. [ABSTRACT FROM AUTHOR]

This work is an attempt to obtain gadolinium-doped hematite Gd x Fe 2−x O 3 (x = 0, 0.05, and 0.1) using the hydrothermal method followed by heat treatment. The work also studies the impact of gadolinium doping on the magnetic, electrical, and optical properties of hematite. X-ray diffraction (XRD) analysis, energy-dispersive X-ray spectroscopy (EDAX) and photoelectron spectroscopy (XPS) showed that the obtained phase for all samples was pure hematite with no evidence of secondary phases, indicating a high solubility limit of gadolinium ions in hematite lattice. The morphology and size distribution of the particles were investigated using high-resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM). It was found that the lattice parameters increased with increasing gadolinium concentration. Magnetization was not enhanced whereas, the coercivity decreased considerably. From UV–Vis diffuse reflection spectroscopy (DRS) measurements, the band gap energies of pure and doped α-Fe 2 O 3 decreased from 2.01 to 1.94 eV respectively. Moreover, measurements of electrical properties showed that the dielectric permittivity decreased while the resistivity increased with increasing the gadolinium content. In addition, sulforhodamine B (SRB) test against oral epithelial cell lines showed low cytotoxicity of the particles. Finally, gadolinium doped hematite is introduced as a novel, environmentally benign material for potential applications in various fields including photocatalysis for water treatment, biosensor and as an antibacterial agent. [Display omitted] • The obtained samples exhibit a corundum structure with no impurities. • The coercivity of hematite decreased whereas saturation magnetization was not enhanced. • The dielectric loss decreased, and the resistivity increased, rendering Gd-doped hematite for microwave applications. • The band gap decrease makes the material useful for photocatalysis, and light energy conversion as a biosensor. • The biocompatibility of the particles makes it a potential material for industrial and medicinal applications. [ABSTRACT FROM AUTHOR]