1. Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE.
- Author
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Wang, Xiaoqi, Bi, Qiuhui, Lu, Jie, Chan, Piu, Hu, Xiaochen, Su, Li, Jessen, Frank, Lin, Hua, Han, Chunlei, Shu, Ni, Liu, Hesheng, and Han, Ying
- Subjects
COGNITION disorders ,AMYLOID ,EPISODIC memory ,MULTIPLE regression analysis ,POSITRON emission tomography ,TEMPORAL lobe ,CLINICAL neuropsychology ,PROTEIN metabolism ,BRAIN ,RESEARCH ,RESEARCH methodology ,EVALUATION research ,NEUROPSYCHOLOGICAL tests ,COMPARATIVE studies ,EMISSION-computed tomography - Abstract
Background: Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention.Objective: We aim to explore the difference in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition.Methods: A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition.Results: Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores.Conclusion: According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals. [ABSTRACT FROM AUTHOR]- Published
- 2022
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