1. Regional Coherence Changes in Alzheimer’s Disease Patients with Depressive Symptoms: A Resting-State Functional MRI Study
- Author
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Hongtao Hou, Fuquan Wei, Luoyi Xu, Xingli Chen, Yingchun Zhang, Jiapeng Li, Lili Wei, Xiaozheng Liu, Xize Jia, Zhongwei Guo, Wei Chen, Yuedi Shen, and Yulin Cao
- Subjects
Male ,medicine.medical_specialty ,Psychosis ,Brain activity and meditation ,Rest ,Disease ,Brain mapping ,Prodrome ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Psychiatry ,Aged ,Psychiatric Status Rating Scales ,Brain Mapping ,medicine.diagnostic_test ,Resting state fMRI ,Depression ,business.industry ,General Neuroscience ,Brain ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Psychiatry and Mental health ,Clinical Psychology ,Female ,Geriatrics and Gerontology ,Alzheimer's disease ,business - Abstract
Alzheimer's disease (AD) is characterized by progressive cognitive decline along with neuropsychiatric symptoms including depression and psychosis. Depression is a common psychiatric disorder occurring in people across the lifespan. Accumulating evidence indicates that depression may be a prodrome and/or a "risk factor" for AD. However, whether AD and depression share a common pathophysiological pathway is still unclear. The aim of this study was to identify regional alterations in brain function associated with depressive symptoms in mild AD patients. Thirty-two mild AD patients were evaluated using the Neuropsychiatric Inventory and Hamilton Depression Rating Scale, and were divided into two groups: 15 AD patients with depressive symptoms (D-AD) and 17 non-depressed AD (nD-AD) patients. Using the approach of regional homogeneity (ReHo), we characterized resting-state regional brain activity in D-AD and nD-AD patients. Compared with nD-AD patients, D-AD patients showed decreased ReHo in the right precentral gyrus, right superior frontal gyrus, right middle frontal gyrus, and right inferior frontal cortex. Our findings show regional brain activity alterations in D-AD patients. Thus, D-AD pathogenesis may be attributed to abnormal neural activity in multiple brain regions.
- Published
- 2015