1. The Synergistic Roles of the Chronic Prenatal and Offspring Stress Exposures in Impairing Offspring Learning and Memory
- Author
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Ke-Yang Chen, Zheng-Yu Wang, Qi-Hong Wang, Yu-You Yao, Juan Cheng, Zhen-Min Han, and Wei Tang
- Subjects
Male ,0301 basic medicine ,Offspring ,Hippocampus ,Mice, Transgenic ,Neuropathology ,Presenilin ,Amyloid beta-Protein Precursor ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pregnancy ,Corticosterone ,Presenilin-1 ,medicine ,Animals ,Chronic stress ,Maze Learning ,Memory Disorders ,Learning Disabilities ,General Neuroscience ,Brain ,Recognition, Psychology ,General Medicine ,Mice, Inbred C57BL ,Disease Models, Animal ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Animals, Newborn ,Gene Expression Regulation ,chemistry ,Prenatal stress ,Prenatal Exposure Delayed Effects ,Mutation ,Exploratory Behavior ,Female ,Geriatrics and Gerontology ,Psychology ,Neuroscience ,Stress, Psychological ,030217 neurology & neurosurgery ,Glucocorticoid ,medicine.drug - Abstract
In Alzheimer's disease (AD), extensive experimental studies have demonstrated a negative impact of chronic stress during various stages of life (including prenatal phase) on some aspects of AD pathology. Nevertheless, presently, few studies have been involved in the learning and memory impairments, as well as neuropathology elicited by the chronic prenatal stress (CPS) and the chronic offspring stress (COS) exposures simultaneously, particularly for the adult male APPswe/PS1dE9 murine offspring. Therefore, the aim of the present study was to investigate the influence of CPS on learning and memory impairments induced by COS in 6-month-old male APPswe/PS1dE9 offspring mice and the related mechanism. Our study firstly demonstrates that 14-day exposure to CPS could exacerbate the learning and memory impairments, as well as neuropathological damages in the CA3 regions of the hippocampus and cortex neurons, which is induced by the 28-day exposure to COS in 6-month-old male APPswe/PS1dE9 offspring mice. In addition, CPS could potentiate the production of AβPP, Aβ42, and corticosterone in 6-month-old male APPswe/PS1dE9 offspring that also suffer COS. In conclusion, our novel findings strongly implicate the synergistic roles of the CPS and COS exposures in impairing offspring learning and memory. Moreover, CPS potentiating the production of Aβ42 might be mediated by glucocorticoids through increasing the expression of APP and BACE1 gene.
- Published
- 2016