1. Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
- Author
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Horst Bickel, Birgitt Wiese, Michael Pentzek, Wolfgang Maier, Frank Jessen, Julie Williams, Cadja Bachmann, Siegfried Weyerer, Hendrik van den Bussche, Steffi G. Riedel-Heller, and Britta Schürmann
- Subjects
Male ,medicine.medical_specialty ,Single-nucleotide polymorphism ,Genome-wide association study ,genetics [Alzheimer Disease] ,Enzyme-Linked Immunosorbent Assay ,Disease ,Bioinformatics ,methods [Genome-Wide Association Study] ,blood [Alzheimer Disease] ,Alzheimer Disease ,Risk Factors ,Internal medicine ,CLU protein, human ,medicine ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,Longitudinal Studies ,genetics [Genetic Predisposition to Disease] ,Aged, 80 and over ,Analysis of Variance ,Clusterin ,biology ,business.industry ,General Neuroscience ,Genetic Variation ,General Medicine ,Plasma levels ,blood [Clusterin] ,eye diseases ,genetics [Genetic Variation] ,Psychiatry and Mental health ,Clinical Psychology ,Increased risk ,Endocrinology ,Risk allele ,biology.protein ,Female ,sense organs ,Analysis of variance ,Geriatrics and Gerontology ,business ,genetics [Clusterin] ,Genome-Wide Association Study - Abstract
A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies. Here we tested the association of the respective single nucleotide polymorphisms (rs11136000) with plasma concentration of clusterin in 67 AD subjects and 191 cognitively unimpaired elderly individuals. We observed an association of the rs11136000 AD-risk variant with low clusterin plasma levels in an allele-dose dependent manner in the healthy individuals (p = 0.011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels.
- Published
- 2011
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