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Numerous studies have established the relationship of SNPs in the leptin gene with fat and energy exchange, nutritional behavior in cattle. In turn, the intensity of metabolic processes in body is determined by the development of internal organs. The purpose of research was to study the relationship between the complex of polymorphisms C73T and C528T in leptin gene for the formation of internal organs in Aberdeen-Angus cows and heifers. Cows (n = 30) and heifers (n = 49) were genotyped and identified respectively 7 and 8 various combinations of genotypes of C73T (GenBank AF120500) and C528T (GenBank AB070368). There were no homozygous CC/CC and TT/TT combinations in cows, and no TT/TT combination in heifers. Cows were slaughtered at the age of 3 years, and heifers - at 20 months. Cows with haplotype CT/CC had the highest liver, heart, lung, kidney and spleen weight with superiority relative to peers of 6.5–16.0% (P > 0.05). The minimum development of stomachs was established at cows with a combination of genotypes of CC/TT which conceded to analogs for 7.6–13.8% (P > 0.05). Haplotypes CT/CT and TT/CT in heifers were associated with greater internal organ massiveness. Carriers of complex CT/CT genotype outperformed peers in terms of liver, heart, lung, kidney and spleen weight by 1.75–6.59% (P < 0.05, P > 0.05), and individuals with a combination of TT/CT by 3.50–8.84% (P < 0.05, P > 0.05). Less developed stomachs were established in bodies with haplotype TT/CC, which were inferior to other genotypes by 1.20–7.49% (P < 0.05, P > 0.05). This indirectly indicates a relatively weak ability to use coarse plant foods. Thus, the complex genotype inleptin gene is associated with the variability in the development of internal organs, which determines the intensity of metabolic processes. This research was performed with financial support from the project of RAS0526-2021-0001.