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Start Over Author "Supothina, Sumalee" Journal journal of antibiotics
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4. Enniatin production by the entomopathogenic fungus Verticillium hemipterigenum BCC 1449.

Author

Supothina S, Isaka M, Kirtikara K, Tanticharoen M, and Thebtaranonth Y

Subjects
Acetylation, Animals, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Antibiotics, Antineoplastic biosynthesis, Antibiotics, Antineoplastic isolation & purification, Antibiotics, Antineoplastic pharmacology, Antibiotics, Antitubercular biosynthesis, Antibiotics, Antitubercular isolation & purification, Antibiotics, Antitubercular pharmacology, Antimalarials isolation & purification, Antimalarials pharmacology, Borohydrides, Cell Line, Tumor, Chromatography, High Pressure Liquid, Culture Media chemistry, Depsipeptides isolation & purification, Depsipeptides pharmacology, Fermentation, Lithium Compounds, Magnetic Resonance Spectroscopy, Plasmodium falciparum drug effects, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Anti-Bacterial Agents biosynthesis, Depsipeptides biosynthesis, Verticillium metabolism
Abstract

Optimal fermentation conditions for enniatin production using the entomopathogenic fungus Verticillium hemipterigenum BCC 1449 have been investigated. Among various liquid media tested, highest efficiency of enniatin production was achieved by fermentation in yeast extract sucrose. Application of this condition to large-scale fermentation resulted in the isolation of three new analogs, O1, O2 and O3, which are closely related isomers that were characterized as an inseparable mixture, along with seven known enniatins.

Published
2004
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