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This study assessed seasonal incidence, economic losses, the efficacy of therapeutic protocols, the recovery time of affected animals and specific prophylactic measures applied to sheep with acute infectious pododermatitis. The studies were conducted over a period of 12 months in 3 different sheep farms from private units in the same area. The results of the study showed an increased incidence of the disease in all 3 farms, with an average of 26.94% of the sheep flock. The incidence of the disease was increased in the months of April-May- June-July and September-October (30%), when there were heavy rains. The high morbidity led to economic losses through the decrease in milk production by approximately 30% and the decrease in the weight of the sheep by 10.58% (4.2 kg) of their normal weight. The therapeutic protocol applied locally as well as parenterally, combined with a foot bath with 10% zinc sulphate solution, were effective in treating acute infectious pododermatitis of sheep. The average recovery time (days) was approximately the same in the three groups of sheep (5.25 ± 0.68 days for cases with moderate diseases and 10.2 ± 0.22 for cases with severe diseases). [ABSTRACT FROM AUTHOR]