1. Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H-NMR spectroscopy
- Author
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Ji-Young Yang, Seul Min Choi, Hyung Sik Kim, Duck Soo Lim, Geum-Sook Hwang, Du Yeon Bang, M.J. Kwon, Seung Jun Kwack, Do Hyun Ryu, Yeon Joo Kim, Seong Kwang Lim, Kyu-Bong Kim, Young Woo Kim, Byung-Mu Lee, and J.Y. Bae
- Subjects
chemistry.chemical_classification ,chemistry.chemical_compound ,Taurine ,Metabolomics ,Chemistry ,Trigonelline ,Urinary system ,Trimethylamine ,Biomarker (medicine) ,Urine ,Tricarboxylic acid ,Pharmacology ,Toxicology - Abstract
A metabolomics approach using proton nuclear magnetic resonance (NMR) was applied to investigate metabolic alterations following adriamycin (ADR) treatment for gastric adenocarcinoma. After BALB/c-nu/nu mice were implanted with human gastric adenocarcinoma, ADR (1 or 3 mg kgā1 per day) was intraperitoneally administered for 5 days. Urine was collected on days 2 and 5 and analyzed by NMR. The levels of trimethylamine oxide (TMAO, ×0.3), hippurate (×0.3) and taurine (×0.6) decreased significantly (P
- Published
- 2012
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