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Abstract: Despite more than 30 years’ studies in the Yarlung Zangbo Suture Zone (YZSZ), southern Tibet is still a region of discovery and the geological evolution of the Neo-Tethys here remains controversial. In this paper we present the new field observation, petrography, zircon U–Pb dating and geochemistry of the Zhongba mafic rocks in the western segment of the YZSZ. Zircon U–Pb analyses from a diabase using SIMS (Secondary Ion Mass Spectrometry) yielded a concordant age of 125.7±0.9Ma. All the Zhongba mafic rocks exhibit LREE enrichment (LaN/YbN =4.7–15.8) without Eu anomalies (δEu=0.97–1.01). Their Primitive-Mantle-normalized trace element patterns are similar to those of the average OIB and Hawaii alkaline basalts, as well as other OIB-type rocks already reported in the central-western YZSZ. These observations lead us to suggest the existence of a series of seamounts within the Neo-Tethys during the Early Cretaceous. These OIB-type rocks could be originated from (1) hotspot mantle; (2) near-ridge seamounts by melting-induced mixing of two distinct mantle sources; (3) late-stage magmatism fed by melts that originated from an asthenospheric window due to slab delamination. Combining literature data from the entire YZSZ, which include studies of the MORB- and IAB-type rocks and mantle peridotites, we prefer the third explanation that the OIB-type rocks represent a late-stage magmatic activity above an intra-oceanic supra-subduction zone within the Neo-Tethys. [Copyright &y& Elsevier]