1. Antimicrobial lanostane triterpenoids from the fruiting bodies of Ganoderma applanatum.
- Author
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Shi, Jing-Xia, Chen, Guo-Yu, Sun, Qian, Meng, Shi-Yang, and Chi, Wei-Qun
- Subjects
FUNGI classification ,METHANE analysis ,IN vitro studies ,TRITERPENES ,CULTURE media (Biology) ,ANTI-infective agents ,FUNGI ,NUCLEAR magnetic resonance spectroscopy ,DOSE-effect relationship in pharmacology ,MOLECULAR structure ,ANALYTICAL chemistry techniques ,INFRARED spectroscopy ,CHROMATOGRAPHIC analysis ,GRAM-positive bacteria ,PHARMACODYNAMICS - Abstract
A chemical investigation on the 90% EtOH extract of the fruiting bodies of Ganoderma applanatum led to the isolation of three new lanostane triterpenoids, designated as 25-methoxy-11-oxo-ganoderiol D (1), 3-oxo-25-methoxy-24,26-dihydroxy-lanosta-7,9(11)-diene (2), and 3β-acetyloxy-lucidone H (3). Structural elucidation of all the compounds were performed by spectral methods such as 1 D and 2 D (
1 H-1 H COSY, HMQC, and HMBC) NMR spectroscopy. All the triterpenoids were in vitro evaluated for their antimicrobial activities against six pathogenic microorganisms. Compounds 1 and 2 exhibited some activities against three Gram positive bacteria with MIC values less than 60 μg/ml. [ABSTRACT FROM AUTHOR]- Published
- 2022
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