1. Six new furostanol glycosides from Smilax glauco - china and their cytotoxic activity.
- Author
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Liu, Xing, Liang, Jian, Pan, Ling-Ling, Chen, Jian-Yong, Liu, Rong-Hua, Zhu, Gen-Hua, Huang, Hui-Lian, Shu, Ji-Cheng, Shao, Feng, Liang, Yong-Hong, and Yu, Jiang-Li
- Subjects
CELL lines ,CHROMATOGRAPHIC analysis ,GLYCOSIDES ,INFRARED spectroscopy ,MEDICINAL plants ,CHINESE medicine ,MOLECULAR structure ,RESEARCH funding ,PLANT roots ,SPECTRUM analysis ,PLANT extracts ,DATA analysis software ,CYTOTOXINS ,DESCRIPTIVE statistics ,IN vitro studies - Abstract
Six new steroidal saponins, namely glauco-chinaosides A–F, and one known compound were isolated from the tubers ofSmilax glauco-china. Their structures were elucidated by a combination of spectroscopic analysis and hydrolysis followed by spectral and chromatographic analysis. Compounds1–7were testedin vitrofor their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, and Lovo). Compounds1,2,and5exhibited cytotoxic activity against SGC-7901, with IC50values of 2.7, 11.5, and 6.8 μM, respectively. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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