1. Two new triterpenoid saponins from rhizome of Anemone amurensis.
- Author
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Lv, Chong-Ning, Fan, Li, Wang, Jing, Qin, Ru-Lan, Xu, Tan-Ye, Lei, Tian-Li, and Lu, Jin-Cai
- Subjects
THIN layer chromatography ,ANTINEOPLASTIC agents ,BIOLOGICAL assay ,CELL culture ,CELL lines ,FLUOROURACIL ,GLYCOSIDES ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,PHARMACEUTICAL chemistry ,RESEARCH funding ,PLANT stems ,TERPENES ,TOXICITY testing ,TUMORS ,REPEATED measures design ,DESCRIPTIVE statistics ,IN vitro studies - Abstract
Two new triterpenoid saponins were isolated from the 70% ethanol extract of the rhizome ofAnemone amurensis, they are oleanolic acid 28-O-β-d-glucopyranosyl-(1 → 3)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranosyl ester (1) and 23,27-dihydroxy oleanolic acid 3-O-α-l-arabinopyranoside (2). The structures of1and2were elucidated on the basis of chemical and spectral analysis, including 1D and 2D NMR data and HR-ESI-MS. Compounds1and2were tested for cytotoxicities against three human cancer cell lines (A549, Hep-G2, and MCF-7). Compound1showed potent cytotoxicity with IC50values of 34.76, 41.17, and 28.92 μM, respectively, while compound2with IC50>100 μM. [ABSTRACT FROM PUBLISHER]
- Published
- 2015
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