1. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity.
- Author
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Wang, Ya-Di, Zhang, Yang, Sun, Bo, Leng, Xiao-Wei, Li, Ya-Juan, and Ren, Li-Qun
- Subjects
ANIMAL experimentation ,ANTHRACYCLINES ,APOPTOSIS ,BIOMARKERS ,CARDIOTOXICITY ,COMPARATIVE studies ,CREATINE kinase ,ELECTROCARDIOGRAPHY ,HEMODYNAMICS ,ISOENZYMES ,MOLECULAR structure ,PEPTIDE hormones ,PROBABILITY theory ,PROTEINS ,RATS ,RUTIN ,TOXICITY testing ,PLANT extracts ,OXIDATIVE stress ,TROPONIN ,PHARMACODYNAMICS - Abstract
We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (
p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (allp < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed. [ABSTRACT FROM AUTHOR]- Published
- 2018
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