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Start Over Author "Xiao, Jia" Topic animal experimentation Topic mice Journal journal of asian natural products research
1 results on '"Xiao, Jia"'

1. Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice.

Author

Li, Jing-Jing, Gao, Hao, Lv, Yi, Li, Mian-Huan, Ren, Chao-Ran, So, Kwok-Fai, and Xiao, Jia

Subjects
ANIMAL experimentation, BIOLOGICAL products, FATTY liver, HEPATITIS, HISTOLOGY, MEDICINAL plants, MICE, ORGANIC compounds, POLYMERASE chain reaction, RESEARCH funding, STATISTICS, WESTERN immunoblotting, DATA analysis, CHRONIC hepatitis B, ONE-way analysis of variance
Abstract

A hepatitis B virus (HBV) transgenic mice model was used to establish the fatty liver superimposed model by feeding the methionine choline-deficient (MCD) diet for 8 weeks, with or without the gavage of 2 mg/kg zeaxanthin dipalmitate (ZD) three times per week. Both wild-type and HBV transgenic mice, with MCD diet, gained typical non-obese non-alcoholic steatohepatitis (NASH) and HBV symptoms. Coadministration with ZD exhibited evident therapeutic effects through alleviating those pathological events. Moreover, long-term vehicle-ZD treatment was found to be safe. Thus, ZD is a promising and safe hepato-protective agent against hepatic injury induced by superimposed HBV and NASH in non-obese mice. [ABSTRACT FROM AUTHOR]

Published
2017
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