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Two unusual novel iridoid glycosides, cornsecoside A (1) and cornsecoside B (2), were isolated from a 40% ethanol elution fraction of a 50% ethanol extract of Cornus officinalis fruit. Their structures were determined by spectroscopic data analysis combined with hydrolysis and ECD spectroscopy. In addition, compounds 1 and 2 exhibited cytotoxic activity against Bel-7402 cells with IC50 values of 8.12 and 9.31 µM, and were neuroprotective against H2O2-induced SH-SY5Y cell injure at a concentration of 10 µM. [ABSTRACT FROM AUTHOR]

Four new iridoid glycosides named cornusphenosides A-D (1-4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1-4 were also assessed in vitro. [ABSTRACT FROM AUTHOR]

Three new iridoids, cornifins A–C (1–3), together with a known iridoid, were obtained from EtOAc layer of leaves ofCornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound2showed weak inhibitory activity against lung cancer cell line A-549 with IC50value of 29.1  μM. [ABSTRACT FROM PUBLISHER]