1. Two new compounds fromKhaya senegalensis
- Author
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Chun-Mao Yuan, Hongping He, Xiao-Ying Wang, Feng Guo, Yu Zhang, Hui-Ming Hua, Tao Zou, Guo-Ying Zuo, Xiao-Jiang Hao, Jin-Hua Liao, and Gui-Hua Tang
- Subjects
Limonins ,Methicillin-Resistant Staphylococcus aureus ,Khayseneganin I ,Stereochemistry ,medicine.medical_treatment ,Pharmaceutical Science ,Microbial Sensitivity Tests ,Limonoid ,Catechin ,Analytical Chemistry ,Steroid ,Khaya ,Drug Discovery ,medicine ,Organic chemistry ,Glycosides ,Meliaceae ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,Molecular Structure ,Plant Stems ,biology ,Chemistry ,Organic Chemistry ,General Medicine ,Pregnanes ,biology.organism_classification ,Antimicrobial ,Anti-Bacterial Agents ,Plant Leaves ,Complementary and alternative medicine ,Molecular Medicine ,Two-dimensional nuclear magnetic resonance spectroscopy ,Drugs, Chinese Herbal ,medicine.drug - Abstract
Two new compounds, khayseneganin I (1) and 2α,3α,16β-trihydroxy-20-acetoxy-20(R)-pregnane (2), along with six known compounds, 2α,3α,20-trihydroxy-16β-acetoxy-20(R)-pregnane (3), 2α,3β-dihydroxypregnan-16-one-2β,19-hemiketal (4), (+)-catechin (5), ivorenolide A (6), luteolin-7-O-α-l-rhamnoside (7), and ( - )-5'-methoxy-isolariciresinol-2a-O-β-d-xylopyranoside (8), were isolated from the leaves and twigs of Khaya senegalensis. The structures of new compounds were elucidated by 2D NMR spectroscopy and MS. Selected compounds (2-8) were evaluated for their antimicrobial activities and compounds 5 and 7 showed weak antimicrobial activities against MRSA 92(#) and MRSA 98(#).
- Published
- 2013