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Start Over Author "Kun Zou" Journal journal of asian natural products research
4 results on '"Kun Zou"'

1. A novel compound from Hedysarum polybotrys

Author

Kun Zou, Katsuko Komatsu, and Shu Zhu

Subjects
Pharmacology, Folk medicine, Magnetic Resonance Spectroscopy, Molecular Structure, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, General Medicine, Plant Roots, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Molecular Medicine, Hedysarum polybotrys, Drugs, Chinese Herbal
Abstract

A polyhydroxyl constituent (1), named as polybotrin, along with two known compounds, were isolated from the roots of Hedysarum polybotrys. Their structures were identified based on chemical and spectroscopic evidence.

Published
2007

2. A pair of isomeric saponins with cytotoxicity fromAlbizzia julibrissin

Author

J.-R. Cui, Bao-Rong Wang, Kun Zou, Yu Ying Zhao, and Ru-Yi Zhang

Subjects
Albizia julibrissin, Spectrophotometry, Infrared, Stereochemistry, Saponin, Tetrazolium Salts, Pharmaceutical Science, Albizzia, HL-60 Cells, Spectrometry, Mass, Fast Atom Bombardment, Pharmacognosy, Analytical Chemistry, Triterpene, Drug Discovery, Humans, Tetrasaccharide, Trisaccharide, Nuclear Magnetic Resonance, Biomolecular, Triterpenoid saponin, Pharmacology, chemistry.chemical_classification, Formazans, Molecular Structure, biology, Organic Chemistry, Glycoside, General Medicine, Saponins, biology.organism_classification, Antineoplastic Agents, Phytogenic, Complementary and alternative medicine, chemistry, Plant Bark, Molecular Medicine, Drug Screening Assays, Antitumor, HeLa Cells
Abstract

Two new saponins have been isolated from the stem barks of Albizzia julibrissin Durazz, and their structures identified as 3-O-[beta-D-xylopyranosyl-(1 --2)-beta-D-fucopyranosyl-(1 --6)-beta-D-2-deoxy-2-acetoamidoglucopyranosyl]-21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-[4-O-((6S)-2-trans-2-hydroxymethyl-6-hydroxy-6-methyl-2,7-octadienoyl)-beta-D-quinovopyranosyl]-2,7-octadienoyl}-acacic acid-28-O-beta-D-glucopyranosyl-(1 --3)-[alpha-L-arabinofuranosyl-(1 --4)]-alpha-L-rhamnopyranosyl-(1 --2)-beta-D-glucopyranosyl ester (1) and 3-O-[beta-D-xylopyranosyl-(1 --2)-beta-D-fucopyranosyl-(1 --6)-beta-D-2-deoxy-2-acetoamidoglucopyranosyl]-21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-[3-O-((6S)-2-trans-2-hydroxymethyl-6-hydroxy-6-methyl-2,7-octadienoyl)-beta-D-quinovopyranosyl]-2,7-octadienoyl}acacic acid 28-O-beta-D-glucopyranosyl-(1 --3)-[alpha-L-arabinofuranosyl-(1 --4)]-alpha-L-rhamnopyranosyl-(1 --2)-beta-D-glucopyranosyl ester (2), based on chemical and spectral evidences, named as julibroside J19 and julibroside J18, respectively. Both compounds show significant inhibition action against HeLa, Bel-7402 and MDA-MB-435 cancer cell lines in vitro.

Published
2005

3. A Triterpenod Saponin fromAlbizia Julibrissin

Author

De-An Guo, Ru-Yi Zhang, Jun-Hua Zheng, Guang-Zhong Tu, Kun Zou, and Yuying Zhao

Subjects
Albizia julibrissin, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Saponin, Pharmaceutical Science, Spectrometry, Mass, Fast Atom Bombardment, Analytical Chemistry, Drug Discovery, Botany, Rosales, Chromatography, High Pressure Liquid, Triterpenoid saponin, Pharmacology, chemistry.chemical_classification, Plant Stems, biology, Traditional medicine, Chemistry, Organic Chemistry, General Medicine, Saponins, biology.organism_classification, Triterpenes, Carbohydrate Sequence, Models, Chemical, Complementary and alternative medicine, Monoterpenes, Molecular Medicine
Abstract

A triterpenoid saponin (1) was obtained from the stem barks of Albizia julibrissin Durazz. Its structure was elucidated as 3-O-[beta-D-xylopyranosyl-(1 --2)-alpha-L-arabinopyranosyl-(1 --6)-beta-D-glucopyranosyl]-21-O-[(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-beta-D-quinovopyranosyl-2, 7-octadienoyl]-16-deoxy-acacic acid 28-O-beta-D-glucopyranosyl-(1 --3)-[alpha-L-arabinofuranosyl-(1 --4)]-alpha-L-rhamnopyranosyl-(1 --2)-beta-D-glucopyranosyl ester (1), named as Julibroside J26, based on the chemical and spectral methods.

Published
1999

4. A New Isomer of Julibroside J2fromAlbizia julibrissin

Author

Kun Zou, Ru-Yi Zhang, Jun-Hua Zheng, Guang-Zhong Tu, and Yuying Zhao

Subjects
Pharmacology, Albizia julibrissin, biology, Stereochemistry, Chemistry, Organic Chemistry, Pharmaceutical Science, General Medicine, biology.organism_classification, Analytical Chemistry, Ethanol extracts, Complementary and alternative medicine, Drug Discovery, Molecular Medicine
Abstract

A new isomer of Julibroside J2 (Chen, S.P., Zhang, R.Y., Ma, L.B. and Tu, G.Z. Acta Pharm. Sinica, 1997, 32, 110–115) was obtained from the cytotoxic fraction of 95% ethanol extracts of stem barks of Albizia julibrissin Durazz, together with Julibroside J2. Its structure was elucidated as 3-O-[β-D-xylopyranosyl-(1 → 2)-α-L-arabinopyranosyl-(1 → 6)-β-D-glucopyranosyl]-21-O-{(6S)-2-trans-2-hydroxymethyl-6-methyl-6-O-[3-O-((6S)-2-trans-2-hydroxymethyl-6-methyl-6-hydroxy-2,7 -octadienoyl)-β-D-quinovopyranosyl]-2,7-octadienoyl} acacic acid 28-O-β-D-glucopyranosyl-(1 → 3)-[α-L-arabinofuranosyl-(1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranosyl ester(1), named as Julibroside J7, based on chemical and spectral methods. Julibroside J2 showed good inhibitory action against KB cell line in vitro.

Published
1998

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