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Tetradium trichotomum Lour., is a plant species endemic to tropical South East Asia with particular medicinal importance. However, very little analysis in this plant has been studied up to now from a phytochemical viewpoint. One new amide alkaloid (wuchuyuamide V, 1), as well as two known amide alkaloids-wuchuyuamide III (2), and wuchuyuamide I (3) were obtained from the fruits of T. trichotomum for the first time. The structures of wuchuyuamide V (1) and wuchuyuamide III (2) were unambiguously elucidated by 1D and 2D-NMR spectra, mass spectrometry, and single-crystal X-ray diffraction. [ABSTRACT FROM AUTHOR]

Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation. Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM. [ABSTRACT FROM AUTHOR]

A new isoflavane, suaeglaucin A (1), which was isolated from the herb of Suaeda glauca (Bunge) Bunge, was elucidated as 5,6,8-trimethoxy-7- hydroxycoumaronochromone based on its MS and 1D and 2D NMR spectroscopic data. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Five known compounds (2-6) were also isolated. All compounds were isolated for the first time from Chenopodiaceae. We found that compounds 2 and 4 possessed moderate antioxidant activity. [ABSTRACT FROM AUTHOR]