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Your search keyword '"Bulut, İsmet"' showing total 3 results
Start Over Author "Bulut, İsmet" Journal journal of asthma
3 results on '"Bulut, İsmet"'

1. Pıcturıng Asthma in Turkey: Results from the Turkısh Adult Asthma Regıstry

Author

Celik, Gulfem Elif, primary, Aydin, Omur, additional, Gokmen, Derya, additional, Buhari, Gozde Koycu, additional, Sozener, Zeynep Celebi, additional, Gemicioglu, Bilun, additional, Bulut, Ismet, additional, Beyaz, Sengul, additional, Orcen, Cihan, additional, Ozdemir, Secil Kepil, additional, Keren, Metin, additional, Damadoglu, Ebru, additional, Yakut, Tugce, additional, Kalpaklioglu, Ayse Fusun, additional, Baccioglu, Ayse, additional, Yalim, Sumeyra Alan, additional, Yilmaz, Insu, additional, Kalkan, Ilkay Koca, additional, Uysal, Mehmet Atilla, additional, Niksarlioglu, Elif Yelda Ozgun, additional, Kalyoncu, Ali Fuat, additional, Karakaya, Gul, additional, Erbay, Muge, additional, Nayci, Sibel, additional, Tepetam, Fatma Merve, additional, Gelincik, Asli Akkor, additional, Dirol, Hulya, additional, Goksel, Ozlem, additional, Karaoglanoglu, Selen, additional, Erkekol, Ferda Oner, additional, Isik, Sacide Rana, additional, Yildiz, Fusun, additional, Yavuz, Yasemin, additional, Karadogan, Dilek, additional, Bozkurt, Nurgul, additional, Seker, Ummuhan, additional, Oguzulgen, Ipek Kivilcim, additional, Basyigit, Ilknur, additional, Baris, Serap Argun, additional, Ucar, Elif Yilmazel, additional, Erdogan, Tuba, additional, Polatli, Mehmet, additional, Ediger, Dane, additional, Gunaydin, Fatma Esra, additional, Turk, Murat, additional, Pur, Leyla, additional, Katran, Zeynep Yegin, additional, Sekibag, Yonca, additional, Aykac, Enes Furkan, additional, Mungan, Dilsad, additional, Gul, Ozcan, additional, Cengiz, Ali, additional, Akkurt, Bulent, additional, Ozden, Seyma, additional, Demir, Semra, additional, Unal, Derya, additional, Aslan, Ayse Feyza, additional, Can, Ali, additional, Gumusburun, Reyhan, additional, Bogatekin, Gulhan, additional, Akten, Hatice Serpil, additional, Inan, Sinem, additional, Erdinc, Munevver, additional, Ogus, Aliye Candan, additional, Kavas, Murat, additional, Yulug, Demet Polat, additional, Cakmak, Mehmet Erdem, additional, Kaya, Saltuk Bugra, additional, Alpagat, Gulistan, additional, Ozgur, Eylem Sercan, additional, Uzun, Oguz, additional, Gulen, Sule Tas, additional, Pekbak, Gulseren, additional, Kizilirmak, Deniz, additional, Havlucu, Yavuz, additional, Donmez, Halil, additional, Arslan, Bahar, additional, Cetin, Gulden Pacaci, additional, Soyyigit, Sadan, additional, Kara, Bilge Yilmaz, additional, Karakis, Gulden Pasaoglu, additional, Dursun, Adile Berna, additional, Kendirlinan, Resat, additional, Ozturk, Ayse Bilge, additional, Sevinc, Can, additional, Simsek, Gokcen Omeroglu, additional, Abadoglu, Oznur, additional, Cerci, Pamir, additional, Yucel, Taskin, additional, Yorulmaz, Irfan, additional, Tezcaner, Zahide Ciler, additional, Tatar, Emel Cadalli, additional, Suslu, Ahmet Emre, additional, Ozer, Serdar, additional, Dursun, Engin, additional, and Yorgancioglu, Arzu, additional

Published
2023
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2. Pregnancy-associated plasma protein-A (PAPP-A) levels in patients with severe allergic asthma are reduced by omalizumab.

Author

Bulut, Ismet, Ozseker, Zeynep F., Coskun, Abdurrahman, Serteser, Mustafa, and Unsal, Ibrahim

Subjects
*IMMUNOGLOBULIN E, *PREGNANCY proteins, *ASTHMATICS, *REGULATION of cell growth, *GROWTH factors, *ASTHMA, *SERUM
Abstract

Background: Remodeling is a crucial feature of severe asthma and may be associated with activation of the allergic cascade by immunoglobulin E (IgE). Omalizumab, an anti-IgE monoclonal antibody, effectively targets the severe allergic asthma phenotype. Pregnancy-associated plasma protein-A (PAPP-A) is an insulin-like growth factor binding protein-4 (IGFBP-4) protease, increasing local insulin-like growth factor (IGF)-1 concentrations, which in turn initiating a cascade involved in the regulation of cell growth, differentiation, and proliferation in various tissues. In the present study, we evaluated the effects of omalizumab on serum PAPP-A, IGFBP-4, and IGF-1 levels in subjects with severe allergic asthma. Methods: We studied 36 asthmatic subjects and 36 healthy controls. An ultrasensitive enzyme-linked immunosorbent assay (ELISA) kit was used to measure serum PAPP-A levels, and routine commercial ELISA kits were employed to assess serum levels of IGF-1, IGFBP-4 in control subjects and asthmatic subjects before therapy (baseline) and after six months of omalizumab therapy in patients with severe asthma. Results: Compared to control subjects, serum PAPP-A and IGFB-4 levels were significantly higher in asthmatic subjects (both p values < 0.001). However, the serum IGF-I levels of asthmatic subjects were similar to those of control subjects (p > 0.05). In asthma subjects, 6-month omalizumab treatment significantly decreased the serum PAPP-A (p < 0.001), IGF-I (p = 0.031), and IGFB4 (p = 0.025) levels. Conclusion: PAPP-A level may be a useful biomarker for predicting airway remodeling in patients with severe asthma receiving omalizumab, and may also reflect the response to treatment. [ABSTRACT FROM AUTHOR]

Published
2018
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