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Your search keyword '"Westerberg, Lisa S."' showing total 4 results
Start Over Author "Westerberg, Lisa S." Journal journal of autoimmunity
4 results on '"Westerberg, Lisa S."'

1. Multi-faceted inhibition of dendritic cell function by CD4+Foxp3+ regulatory T cells

Author

Seitz, Christina, primary, Liu, Sang, additional, Klocke, Katrin, additional, Joly, Anne-Laure, additional, Czarnewski, Paulo V., additional, Tibbitt, Christopher A., additional, Parigi, Sara M., additional, Westerberg, Lisa S., additional, Coquet, Jonathan M., additional, Villablanca, Eduardo J., additional, Wing, Kajsa, additional, and Andersson, John, additional

Published
2019
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3. Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

Author

Dahlberg, Carin I.M., primary, Torres, Magda-Liz, additional, Petersen, Sven H., additional, Baptista, Marisa A.P., additional, Keszei, Marton, additional, Volpi, Stefano, additional, Grasset, Emilie K., additional, Karlsson, Mikael C.I., additional, Walter, Jolan E., additional, Snapper, Scott B., additional, Notarangelo, Luigi D., additional, and Westerberg, Lisa S., additional

Published
2015
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4. Multi-faceted inhibition of dendritic cell function by CD4 + Foxp3 + regulatory T cells.

Author

Seitz C, Liu S, Klocke K, Joly AL, Czarnewski PV, Tibbitt CA, Parigi SM, Westerberg LS, Coquet JM, Villablanca EJ, Wing K, and Andersson J

Subjects
Animals, CD4 Antigens metabolism, CTLA-4 Antigen genetics, Cell Differentiation, Cells, Cultured, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Gene Expression Profiling, Lymphocyte Activation, Lymphoproliferative Disorders genetics, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pneumonia genetics, Programmed Cell Death 1 Ligand 2 Protein genetics, Programmed Cell Death 1 Ligand 2 Protein metabolism, Protein Isoforms genetics, CTLA-4 Antigen metabolism, Dendritic Cells immunology, Lymphoproliferative Disorders immunology, Pneumonia immunology, T-Lymphocytes, Regulatory immunology
Abstract

CTLA-4 is required for CD4 + Foxp3 + regulatory T (Treg) cell function, but its mode of action remains incompletely defined. Herein we generated Ctla-4 ex2fl/fl Foxp3-Cre mice with Treg cells exclusively expressing a naturally occurring, ligand-independent isoform of CTLA-4 (liCTLA-4) that cannot interact with the costimulatory molecules CD80 and CD86. The mice did not exhibit any signs of effector T cell activation early in life, however, at 6 months of age they exhibited excessive T cell activation and inflammation in lungs. In contrast, mice with Treg cells completely lacking CTLA-4 developed lymphoproliferative disease characterized by multi-organ inflammation early in life. In vitro, Treg cells exclusively expressing liCTLA-4 inhibited CD80 and CD86 expression on dendritic cells (DC). Conversely, Treg cells required the extra-cellular part of CTLA-4 to up-regulate expression of the co-inhibitory molecule PD-L2 on DCs. Transcriptomic analysis of suppressed DCs revealed that Treg cells induced a specific immunosuppressive program in DCs., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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