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Your search keyword '"Christine, Aldridge"' showing total 2 results
Start Over Author "Christine, Aldridge" Journal journal of bacteriology
2 results on '"Christine, Aldridge"'

1. FliZ Induces a Kinetic Switch in Flagellar Gene Expression

Author

Santosh Koirala, Ido Golding, Phillip D. Aldridge, Christine Aldridge, Patrick J. Mears, Supreet Saini, Yann R. Chemla, Emily Floess, and Christopher V. Rao

Subjects
Regulation of gene expression, Genetics, Time Factors, Activator (genetics), Extramural, Salmonella enterica, Gene Expression Regulation, Bacterial, Biology, Flagellum, biology.organism_classification, Microbiology, Cell biology, Bacterial protein, Kinetics, Bacterial Proteins, Flagella, Gene expression, Gene Regulation, Molecular Biology
Abstract

FliZ is an activator of class 2 flagellar gene expression in Salmonella enterica . To understand its role in flagellar assembly, we investigated how FliZ affects gene expression dynamics. We demonstrate that FliZ participates in a positive-feedback loop that induces a kinetic switch in class 2 gene expression.

Published
2010
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2. Flagellin redundancy in Caulobacter crescentus and its implications for flagellar filament assembly

Author

Giulia Grimaldi, Phillip D. Aldridge, Tohru Minamino, Jay X. Tang, Wendy D. Smith, Guanglai Li, Keiichi Namba, Joe Gray, Tomoko Miyata, Alexandra Faulds-Pain, Christine Aldridge, Shuichi Nakamura, and Christopher Birchall

Subjects
Genetics, biology, Caulobacter crescentus, Macromolecular Substances, Physiology and Metabolism, Mutant, Caulobacteraceae, Motility, Flagellum, biology.organism_classification, Microbiology, Phenotype, Cell biology, Protein filament, Microscopy, Electron, Flagella, Genes, Bacterial, biology.protein, bacteria, Molecular Biology, Flagellin, Gene Deletion, Locomotion
Abstract

Bacterial flagella play key roles in surface attachment and host-bacterial interactions as well as driving motility. Here, we have investigated the ability of Caulobacter crescentus to assemble its flagellar filament from six flagellins: FljJ, FljK, FljL, FljM, FljN, and FljO. Flagellin gene deletion combinations exhibited a range of phenotypes from no motility or impaired motility to full motility. Characterization of the mutant collection showed the following: (i) that there is no strict requirement for any one of the six flagellins to assemble a filament; (ii) that there is a correlation between slower swimming speeds and shorter filament lengths in Δ fljK Δ fljM mutants; (iii) that the flagellins FljM to FljO are less stable than FljJ to FljL; and (iv) that the flagellins FljK, FljL, FljM, FljN, and FljO alone are able to assemble a filament.

Published
2011

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