1. Characterization of the Type 8 Capsular Gene Cluster of Streptococcus pneumoniae
- Author
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Rosario Muñoz, Ernesto García, Marta Mollerach, and Rubens López
- Subjects
Molecular Sequence Data ,Genetics and Molecular Biology ,Biology ,medicine.disease_cause ,Microbiology ,chemistry.chemical_compound ,Biosynthesis ,Sequence Homology, Nucleic Acid ,Streptococcus pneumoniae ,Gene cluster ,medicine ,Molecular Biology ,Gene ,Genetics ,Base Sequence ,Strain (chemistry) ,Polysaccharides, Bacterial ,Nucleic acid sequence ,Open reading frame ,Carbohydrate Sequence ,chemistry ,Genes, Bacterial ,Multigene Family ,DNA - Abstract
The complete nucleotide sequence of the capsular gene cluster ( cap8 ) responsible for the biosynthesis of the capsular polysaccharide of Streptococcus pneumoniae type 8 has been determined. The cap8 gene cluster, located between the genes dexB and aliA , is composed of 12 open reading frames. A 14.7-kb DNA fragment embracing the cap8 genes was sufficient to transform an unencapsulated type 3 S. pneumoniae strain to a strain with the type 8 capsule. A possible scenario for the evolution of pneumococcal types 2 and 8 is outlined. more...
- Published
- 1999
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