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Introduction: Although drug poisoning rarely occurs during the neonatal period,morbidity and mortality are high when it occurs.Two cases who were admitted to the Emergency Department of our hospital due to digoxin and phenobarbital poisoning with a two-month interval were presented to draw attention to drug poisoning during neonatal period. Case1: A 3335gr girl was admitted to the Newborn Intensive Care Unit on the postnatal day 6 due to atrioventricular block and hyperpotasemia because of the administration of 1 teaspoon of digoxin by the family 72 hours after the diagnosis of ventricular septal defect.The patient was closely monitored by administering digoxin immun Fab once.On the 13th postnatal day,she was discharged with full recovery. Case2: A 3170gr girl was admitted to the emergency department due to respiratory depression and lethargy after 5mg/kg/day phenobarbital treatment was started at the external center with the diagnosis of prolonged jaundice on postnatal day 12 following an administration of 29mg/kg /day with wrong preparation of pharmacy.She was admitted to the Newborn Intensive Care Unit.The patient's phenobarbital blood level was 94.5μg /ml(N: 10-40μg /ml).Phenobarbital treatment was discontinued and the patient was monitored with nasal ventilation support for 3 days and discharged with full recovery on the 9th day of the follow-up. Discussion: Unnecessary drug initiation should be avoided in newborns,and the use of drugs whose therapeutic range is very narrow such as digoxin should be limited,except for congestive heart disease.Alternative treatments and drugs used by your mother and baby should be questioned comprehensively in every newborn case who applies with ambiguous complaints.

INTRODUCTION: The deficiency or absence of an enzyme or cofactor in the metabolic pathway leads to the formation or accumulation of a specific metabolite resulting in inborn errors of metabolism (IEM).The neonate who is, usually, born healthy at birth, will present symptoms such as a reduced activity, nutritional disorders, difficulty in breathing, changes in consciousness, or seizures within hours or days after birth.Since these symptoms are not specific to IEM, a high degree of clinical suspicion is essential in diagnosing and treating the disease and to prevent complications and death.The aim of this study was to evaluate the clinical and biochemical characteristics of neonates diagnosed with IEM. METHODS: Neonates who presented to the Neonatal Intensive Care Unit of X Hospital between 01.02.2015 and 01.02.2018 were included.Demographic and clinical features and laboratory findings of the neonates were retrieved from patients' records. RESULTS: Thirty-three patients with IEM were enrolled into the study.The median birth weight was 3000(interquartile range: 2865-3300) gr, the median gestational week was 39(interquartile range: 38 to 40). The most common presenting complaints were nutritional disorders and tachypnea with a rate of 45.5% which were followed by transaminase elevation(36.4%), hyperammonemia(36.4%), metabolic acidosis(33.3%) and hypoglycemia(27.3%).The most common diagnoses were galactosemia(21.2%), Zellweger syndrome(9.1%) and non-ketotic hyperglycinemia(9.1%).Overall, 64.7% of the patients were discharged with corrected laboratory values. DISCUSSION AND CONCLUSION: Nonspecific symptoms such as nutritional disorders, tachypnea, and jaundice, or nonspecific laboratory abnormalities such as metabolic acidosis or transaminase elevation should alert the physician for IEMs, particularly in countries where the prevalence of consanguineous marriages is high, such as Turkey.