1. Toxicity of iron oxide nanoparticles: Size and coating effects
- Author
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Alexander G. Majouga, Daniil A. Vishnevskiy, Maxim A. Abakumov, Anna V. Ivanova, A. S. Semkina, G. A. Davydova, Vladimir P. Chekhonin, E. V. Mironova, and Alexander Skorikov
- Subjects
0301 basic medicine ,Biocompatibility ,Cell Survival ,Health, Toxicology and Mutagenesis ,Iron oxide ,Nanoparticle ,02 engineering and technology ,Polyethylene glycol ,Toxicology ,Biochemistry ,Ferric Compounds ,Nanomaterials ,Polyethylene Glycols ,03 medical and health sciences ,chemistry.chemical_compound ,Coated Materials, Biocompatible ,Cell Line, Tumor ,Animals ,Humans ,Particle Size ,Cytotoxicity ,Biology ,Molecular Biology ,Cells, Cultured ,Chemistry ,Pharmacology. Therapy ,Serum Albumin, Bovine ,General Medicine ,Fibroblasts ,021001 nanoscience & nanotechnology ,030104 developmental biology ,Molecular Medicine ,Magnetic nanoparticles ,Nanoparticles ,Comet Assay ,0210 nano-technology ,Glioblastoma ,Reactive Oxygen Species ,Iron oxide nanoparticles ,Nuclear chemistry - Abstract
Toxicological research of novel nanomaterials is a major developmental step of their clinical approval. Since iron oxide magnetic nanoparticles have a great potential in cancer treatment and diagnostics, the investigation of their toxic properties is very topical. In this paper we synthesized bovine serum albumin-coated iron oxide nanoparticles with different sizes and their polyethylene glycol derivative. To prove high biocompatibility of obtained nanoparticles the number of in vitro toxicological tests on human fibroblasts and U251 glioblastoma cells was performed. It was shown that albumin nanoparticles' coating provides a stable and biocompatible shell and prevents cytotoxicity of magnetite core. On long exposure times (48 hours), cytotoxicity of iron oxide nanoparticles takes place due to free radical production, but this toxic effect may be neutralized by using polyethylene glycol modification. more...
- Published
- 2018