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2. α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices
3. Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease
4. MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery
5. A proposed pathway from D-glucose to D-arabinose in eukaryotes.
6. Hhatl ameliorates endoplasmic reticulum stress through autophagy by associating with LC3.
7. Novel class of peptides disintegrating biological membranes to aid in the characterization of membrane proteins.
8. Collagen IV of basement membranes: II. Emergence of collagen IVα345 enabled the assembly of a compact GBM as an ultrafilter in mammalian kidneys.
9. Proteomic mapping reveals dysregulated angiogenesis in the cerebral arteries of rats with early-onset hypertension
10. Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics
11. APOLLO, a testis-specific Drosophila ortholog of importin-4, mediates the loading of protamine-like protein Mst77F into sperm chromatin
12. CLPX regulates mitochondrial fatty acid β-oxidation in liver cells
13. Structure and function analysis of a type III preQ1-I riboswitch from E. coli reveals direct metabolite-sensing by the Shine-Dalgarno sequence
14. A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copper
15. Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation
16. Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation
17. The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5
18. Novel exported fusion enzymes with chorismate mutase and cyclohexadienyl dehydratase activity: shikimate pathway enzymes teamed up in no man's land
19. Single-molecule analysis reveals that a glucagon-bound extracellular domain of the glucagon receptor is dynamic
20. Molecular dynamics simulations support a multi-step pathway for activation of branched actin filament nucleation by Arp2/3 complex
21. Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells
22. G-quadruplex in Hepatitis B Virus pregenomic RNA Promotes its Translation
23. A Chicken Tapasin ortholog can chaperone empty HLA-B*37:01 molecules independent of other peptide-loading components
24. Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding
25. The “life-span” of lytic polysaccharide monooxygenases (LPMOs) correlates to the number of turnovers in the reductant peroxidase reaction
26. Increased Phospholipid Flux Bypasses Overlapping Essential Requirements for the Yeast Sac1p Phosphoinositide Phosphatase and ER-PM Membrane Contact Sites
27. The disordered C terminus of ALKBH5 promotes phase separation and paraspeckles assembly
28. A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities
29. ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells
30. Localized Leishmania major infection disrupts systemic iron homeostasis that can be controlled by oral iron supplementation
31. Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome
32. Characterization of a novel cysteine-less Cu/Zn-superoxide dismutase in Paenibacillus lautus missing a conserved disulfide bond
33. NPC1 plays a role in the trafficking of specific cargo to melanosomes
34. Promoter proximal nucleosomes attenuate RNA polymerase II transcription through TFIID
35. Ornithine is the central intermediate in the arginine degradative pathway and its regulation in Bacillus subtilis
36. Lack of polyamines leads to co-translational degradation of the general stress factor RpoS in Escherichia coli
37. A DNAzyme-enhanced nonlinear hybridization chain reaction for sensitive detection of microRNA.
38. Using T4 genetics and Laemmli's development of high-resolution SDS gel electrophoresis to reveal structural protein interactions controlling protein folding and phage self-assembly.
39. A protein bridge to death between the ER and mitochondria.
40. Withdrawal: Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation.
41. Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT
42. Using T4 genetics and Laemmli’s development of high-resolution SDS gel electrophoresis to reveal structural protein interactions controlling protein folding and phage self-assembly
43. New insights into P2X7 receptor regulation: Ca2+-calmodulin and GDP bind to the soluble P2X7 ballast domain
44. High resolution analysis of proteolytic substrate processing.
45. Aberrant overexpression of myosin 1b in glioblastoma promotes angiogenesis via VEGF-myc-myosin 1b-Piezo1 axis.
46. The N-acetylglucosaminyltransferase Radical Fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants.
47. HIRA complex deposition of histone H3.3 is driven by histone tetramerization and histone-DNA binding.
48. Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction.
49. PolyQ-expanded ataxin-2 aggregation impairs cellular processing-body homeostasis via sequestering the RNA helicase DDX6.
50. Circular RNA circMYLK4 shifts energy metabolism from glycolysis to OXPHOS by binding to the calcium channel auxiliary subunit CACNA2D2.
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