Search

Your search keyword '"Eder, Sandra"' showing total 4 results
Start Over Author "Eder, Sandra" Journal journal of biological chemistry
4 results on '"Eder, Sandra"'

1. Functional Cardiac Lipolysis in Mice Critically Depends on Comparative Gene Identification-58

Author

Zierler, Kathrin A., primary, Jaeger, Doris, additional, Pollak, Nina M., additional, Eder, Sandra, additional, Rechberger, Gerald N., additional, Radner, Franz P.W., additional, Woelkart, Gerald, additional, Kolb, Dagmar, additional, Schmidt, Albrecht, additional, Kumari, Manju, additional, Preiss-Landl, Karina, additional, Pieske, Burkert, additional, Mayer, Bernd, additional, Zimmermann, Robert, additional, Lass, Achim, additional, Zechner, Rudolf, additional, and Haemmerle, Guenter, additional

Published
2013
Full Text
View/download PDF

2. Growth Retardation, Impaired Triacylglycerol Catabolism, Hepatic Steatosis, and Lethal Skin Barrier Defect in Mice Lacking Comparative Gene Identification-58 (CGI-58)

Author

Radner, Franz P.W., primary, Streith, Ingo E., additional, Schoiswohl, Gabriele, additional, Schweiger, Martina, additional, Kumari, Manju, additional, Eichmann, Thomas O., additional, Rechberger, Gerald, additional, Koefeler, Harald C., additional, Eder, Sandra, additional, Schauer, Silvia, additional, Theussl, H. Christian, additional, Preiss-Landl, Karina, additional, Lass, Achim, additional, Zimmermann, Robert, additional, Hoefler, Gerald, additional, Zechner, Rudolf, additional, and Haemmerle, Guenter, additional

Published
2010
Full Text
View/download PDF

4. The Yeast Plasma Membrane Protein Alr1 Controls Mg2+Homeostasis and Is Subject to Mg2+-dependent Control of Its Synthesis and Degradation*

Author

Graschopf, Anton, Stadler, Jochen A., Hoellerer, Maria K., Eder, Sandra, Sieghardt, Monika, Kohlwein, Sepp D., and Schweyen, Rudolf J.

Abstract

The Saccharomyces cerevisiae ALR1(YOL130w) gene product Alr1p is the first known candidate for a Mg2+transport system in eukaryotic cells and is distantly related to the bacterial CorA Mg2+transporter family. Here we provide the first experimental evidence for the location of Alr1p in the yeast plasma membrane and for the tight control of its expression and turnover by Mg2+. Using well characterizednpi1and end3mutants deficient in the endocytic pathway, we demonstrate that Alr1 protein turnover is dependent on ubiquitination and endocytosis. Furthermore, cells lacking the vacuolar protease Pep4p accumulated Alr1p in the vacuole. Mutants lacking Alr1p (Δalr1) showed a 60% reduction of total intracellular Mg2+compared with the wild type and failed to grow in standard media. When starved of Mg2+, mutant and wild-type cells had similar low levels of intracellular Mg2+; but upon addition of Mg2+, wild-type cells replenished the intracellular Mg2+pool within a few hours, whereasΔalr1mutant cells did not. Expression of the bacterial Mg2+transporter CorA in the yeastΔalr1mutant partially restored growth in standard media. The results are discussed in terms of Alr1p being a plasma membrane transporter with high selectivity for Mg2+.

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results