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Start Over Author "Sha, Bingdong" Journal journal of biological chemistry
5 results on '"Sha, Bingdong"'

4. Crystal Structure of the Cytoskeleton-associated Protein Glycine-rich (CAP-Gly) Domain

Author

Li, Songlin, primary, Finley, Jim, additional, Liu, Zhi-Jie, additional, Qiu, Shi-Hong, additional, Chen, Hongli, additional, Luan, Chi-Hao, additional, Carson, Mike, additional, Tsao, Jun, additional, Johnson, David, additional, Lin, Guangda, additional, Zhao, Jun, additional, Thomas, Willie, additional, Nagy, Lisa A., additional, Sha, Bingdong, additional, DeLucas, Lawrence J., additional, Wang, Bi-Cheng, additional, and Luo, Ming, additional

Published
2002
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5. Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation.

Author

Hong Wen, Jingzhi Li, Tanjing Song, Ming Lu, Pu-Yeh Kan, Lee, Min Gyu, Sha, Bingdong, and Shi, Xiaobing

Subjects
*HISTONES, *LYSINE, *METHYLATION, *RECOMBINANT DNA, *CRYSTALLOGRAPHY
Abstract

Distinct lysine methylation marks on histones create dynamic signatures deciphered by the "effector" modules, although the underlying mechanisms remain unclear. We identified the plant homeodomainand Jumonji C domain-containing protein PHF2 as a novel histone H3K9 demethylase. We show in biochemical and crystallographic analyses that PHF2 recognizes histone H3K4 trimethylation through its plant homeodomain finger and that this interaction is essential for PHF2 occupancy and H3K9 demethylation at rDNA promoters. Our study provides molecular insights into the mechanism by which distinct effector domains within a protein cooperatively modulate the "cross-talk" of histone modifications. [ABSTRACT FROM AUTHOR]

Published
2010
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