1. PEI-modified diatomite/chitosan composites as bone tissue engineering scaffold for sustained release of BMP-2
- Author
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Ran Li, Haifeng Liu, Junyu Liu, Wenjuan Ren, Ruxia Hou, Yufang Li, Lu Wang, Xiangyu Wang, and Shouji Du
- Subjects
Scaffold ,Bone disease ,0206 medical engineering ,Biomedical Engineering ,Biophysics ,Bioengineering ,02 engineering and technology ,Bone healing ,Bone morphogenetic protein 2 ,Bone tissue engineering ,Biomaterials ,Chitosan ,chemistry.chemical_compound ,Osteogenesis ,medicine ,Polyethyleneimine ,Tissue Engineering ,Tissue Scaffolds ,021001 nanoscience & nanotechnology ,medicine.disease ,020601 biomedical engineering ,Diatomaceous Earth ,chemistry ,Delayed-Action Preparations ,Drug delivery ,0210 nano-technology ,Protein adsorption ,Biomedical engineering - Abstract
The bone healing defects resulting from bone disease remain a significant clinical challenge. The bone tissue engineering scaffolds combined with osteoinductive compounds represent an effective approach to overcome this challenge. In this study, a novel chitosan-based scaffold was prepared by incorporating modified natural diatomite (DE) as filler and adsorption element. Specifically, modified-diatomite (MDE) was synthesized by grafting polyethyleneimine (PEI) on the surface of diatomite
- Published
- 2021