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Your search keyword '"Blaauw, E H"' showing total 5 results
Start Over Author "Blaauw, E H" Journal journal of biomedical materials research
5 results on '"Blaauw, E H"'

5. Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide-epsilon-caprolacton) nerve guide.

Author

den Dunnen WF, Stokroos I, Blaauw EH, Holwerda A, Pennings AJ, Robinson PH, and Schakenraad JM

Subjects
Animals, Biotransformation, Male, Microscopy, Electron, Nerve Fibers physiology, Nerve Fibers ultrastructure, Nerve Fibers, Myelinated physiology, Nerve Fibers, Myelinated ultrastructure, Prostheses and Implants, Rats, Rats, Wistar, Sciatic Nerve cytology, Time Factors, Biocompatible Materials, Nerve Regeneration, Polyesters chemical synthesis, Polyesters pharmacokinetics, Sciatic Nerve physiology, Sciatic Nerve surgery
Abstract

The aim of this study was to evaluate short-term peripheral nerve regeneration across a 10-mm. gap, using a biodegradable poly(DL-lactide-epsilon-caprolacton) nerve guide, with an internal diameter of 1.5 mm and a wall thickness of 0.30 mm. To do so, we evaluated regenerating nerves using light microscopy, transmission electron microscopy and morphometric analysis after implantation of 12-mm nerve guides in the sciatic nerve of the rat. Evaluation times ranged from 3-10 weeks. Three weeks after reconstruction, myelinated nerve fibers could be observed in the distal nerve stump. Ten weeks after reconstruction, the regenerating nerves already resembled normal nerves. In conclusion, we show that poly(DL-lactide-epsilon-caprolacton) nerve guides can be successfully applied in the reconstruction of severed nerves in the rat model. Furthermore, we have observed the fastest nerve regeneration described thus far, after reconstruction using a biodegradable nerve guide.

Published
1996
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