13 results on '"Guoqiang Yu"'
Search Results
2. Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor
- Author
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Mingjun Zhao, Henrietta S. Bada, Chong Huang, Xuhui Liu, Yutong Gu, Yanda Cheng, Guoqiang Yu, Lei Chen, and Elie G. Abu Jawdeh
- Subjects
Paper ,Adult ,Materials science ,Biomedical Engineering ,01 natural sciences ,Imaging phantom ,wearable ,010309 optics ,Biomaterials ,Speckle pattern ,Wearable Electronic Devices ,0103 physical sciences ,blood oxygenation ,medicine ,Special Series on Wearable, Implantable, Mobile, and Remote Biomedical Optics and Photonics ,blood flow ,Humans ,Artery occlusion ,Oximetry ,CMOS sensor ,Phantoms, Imaging ,Hemodynamics ,Blood flow ,Oxygenation ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,deep tissue ,Light intensity ,Forearm ,medicine.anatomical_structure ,speckle contrast ,Biomedical engineering ,Artery - Abstract
Significance: There is an essential need to develop wearable multimodality technologies that can continuously measure both blood flow and oxygenation in deep tissues to investigate and manage various vascular/cellular diseases. Aim: To develop a wearable dual-wavelength diffuse speckle contrast flow oximetry (DSCFO) for simultaneous measurements of blood flow and oxygenation variations in deep tissues. Approach: A wearable fiber-free DSCFO probe was fabricated using 3D printing to confine two small near-infrared laser diodes and a tiny CMOS camera in positions for DSCFO measurements. The spatial diffuse speckle contrast and light intensity measurements at the two different wavelengths enable quantification of tissue blood flow and oxygenation, respectively. The DSCFO was first calibrated using tissue phantoms and then tested in adult forearms during artery cuff occlusion. Results: Phantom tests determined the largest effective source–detector distance (15 mm) and optimal camera exposure time (10 ms) and verified the accuracy of DSCFO in measuring absorption coefficient variations. The DSCFO detected substantial changes in forearm blood flow and oxygenation resulting from the artery occlusion, which meet physiological expectations and are consistent with previous study results. Conclusions: The wearable DSCFO may be used for continuous and simultaneous monitoring of blood flow and oxygenation variations in freely behaving subjects.
- Published
- 2021
3. Noncontact speckle contrast diffuse correlation tomography of blood flow distributions in tissues with arbitrary geometries
- Author
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Ahmed A. Bahrani, Lesley Wong, Mingjun Zhao, Nneamaka Agochukwu, Chong Huang, Guoqiang Yu, and Siavash Mazdeyasna
- Subjects
Materials science ,Biomedical Engineering ,Iterative reconstruction ,01 natural sciences ,Surgical Flaps ,Imaging ,030218 nuclear medicine & medical imaging ,010309 optics ,Biomaterials ,Necrosis ,03 medical and health sciences ,Speckle pattern ,0302 clinical medicine ,Image Interpretation, Computer-Assisted ,0103 physical sciences ,Humans ,Tomography, Optical ,Mastectomy ,Image restoration ,Blood flow ,Atomic and Molecular Physics, and Optics ,Diffuse optical imaging ,Electronic, Optical and Magnetic Materials ,Forearm ,Photometric stereo ,Regional Blood Flow ,Female ,Tomography ,Preclinical imaging ,Biomedical engineering - Abstract
A noncontact electron multiplying charge-coupled-device (EMCCD)-based speckle contrast diffuse correlation tomography (scDCT) technology has been recently developed in our laboratory, allowing for noninvasive three-dimensional measurement of tissue blood flow distributions. One major remaining constraint in the scDCT is the assumption of a semi-infinite tissue volume with a flat surface, which affects the image reconstruction accuracy for tissues with irregular geometries. An advanced photometric stereo technique (PST) was integrated into the scDCT system to obtain the surface geometry in real time for image reconstruction. Computer simulations demonstrated that a priori knowledge of tissue surface geometry is crucial for precisely reconstructing the anomaly with blood flow contrast. Importantly, the innovative integration design with one single-EMCCD camera for both PST and scDCT data collection obviates the need for offline alignment of sources and detectors on the tissue boundary. The in vivo imaging capability of the updated scDCT is demonstrated by imaging dynamic changes in forearm blood flow distribution during a cuff-occlusion procedure. The feasibility and safety in clinical use are evidenced by intraoperative imaging of mastectomy skin flaps and comparison with fluorescence angiography.
- Published
- 2018
4. Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise
- Author
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Sibu P. Saha, D. Travis Thomas, Mingjun Zhao, Brad A. Henry, Eleftherios S. Xenos, Timothy L. Uhl, Yu Shang, and Guoqiang Yu
- Subjects
Adult ,Male ,Optics and Photonics ,Biomedical Engineering ,Hemodynamics ,Gating ,Isometric exercise ,Biomaterials ,Hemoglobins ,Oxygen Consumption ,Forearm ,Research Papers: General ,Isometric Contraction ,Occlusion ,Medicine ,Plethysmograph ,Humans ,Muscle, Skeletal ,Exercise ,Oxygen saturation (medicine) ,business.industry ,Anatomy ,Blood flow ,Atomic and Molecular Physics, and Optics ,Healthy Volunteers ,Electronic, Optical and Magnetic Materials ,Oxygen ,medicine.anatomical_structure ,Lower Extremity ,Calibration ,Female ,business ,Algorithms ,Blood Flow Velocity ,Biomedical engineering - Abstract
Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of forearm muscle hemodynamics during handgrip exercises. The translation of these techniques from the forearm to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin concentrations, blood oxygen saturation, and relative changes in blood flow (rBF) and oxygen consumption rate (rV˙O2). We calibrated rBF and rV˙O2 profiles with absolute baseline values of BF and V˙O2 obtained by venous and arterial occlusions, respectively. Results from this investigation were comparable to values from similar studies. Additionally, significant correlation was observed between resting local muscle BF measured by the optical technique and whole limb BF measured concurrently by a strain gauge venous plethysmography. The extensive hemodynamic and metabolic profiles during exercise will allow for future comparison studies to investigate the diagnostic value of hybrid technologies in muscles affected by disease.
- Published
- 2015
5. Noncontact diffuse optical assessment of blood flow changes in head and neck free tissue transfer flaps
- Author
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Thomas J. Gal, Yu Shang, Guoqiang Yu, Chong Huang, Amit B. Patel, Rony K. Aouad, Jeffrey P. Radabaugh, Joseph Valentino, and Yu Lin
- Subjects
Male ,medicine.medical_specialty ,Biomedical Engineering ,Anastomosis ,Free Tissue Flaps ,Biomaterials ,Vascularity ,Research Papers: General ,medicine ,Humans ,Stage (cooking) ,Aged ,Spectroscopy, Near-Infrared ,business.industry ,Head and neck cancer ,Diffuse correlation spectroscopy ,Blood flow ,Equipment Design ,Middle Aged ,medicine.disease ,Thrombosis ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Tissue transfer ,Surgery ,Head and Neck Neoplasms ,Regional Blood Flow ,Female ,medicine.symptom ,business ,Head ,Neck - Abstract
Knowledge of tissue blood flow (BF) changes after free tissue transfer may enable surgeons to predict the failure of flap thrombosis at an early stage. This study used our recently developed noncontact diffuse correlation spectroscopy to monitor dynamic BF changes in free flaps without getting in contact with the targeted tissue. Eight free flaps were elevated in patients with head and neck cancer; one of the flaps failed. Multiple BF measurements probing the transferred tissue were performed during and post the surgical operation. Postoperative BF values were normalized to the intraoperative baselines (assigning "1") for the calculation of relative BF change (rBF). The rBF changes over the seven successful flaps were 1.89 ± 0.15, 2.26 ± 0.13, and 2.43 ± 0.13 (mean ± standard error), respectively, on postoperative days 2, 4, and 7. These postoperative values were significantly higher than the intraoperative baseline values (p0.001), indicating a gradual recovery of flap vascularity after the tissue transfer. By contrast, rBF changes observed from the unsuccessful flaps were 1.14 and 1.34, respectively, on postoperative days 2 and 4, indicating less flow recovery. Measurement of BF recovery after flap anastomosis holds the potential to act early to salvage ischemic flaps.
- Published
- 2015
6. Noncontact speckle contrast diffuse correlation tomography of blood flow distributions in tissues with arbitrary geometries.
- Author
-
Mazdeyasna, Siavash, Chong Huang, Mingjun Zhao, Agochukwu, Nneamaka B., Bahrani, Ahmed A., Wong, Lesley, and Guoqiang Yu
- Subjects
CHARGE coupled devices ,BLOOD flow ,PHOTOMETRIC stereo ,MASTECTOMY ,SURFACE geometry - Abstract
A noncontact electron multiplying charge-coupled-device (EMCCD)-based speckle contrast diffuse correlation tomography (scDCT) technology has been recently developed in our laboratory, allowing for noninvasive three-dimensional measurement of tissue blood flow distributions. One major remaining constraint in the scDCT is the assumption of a semi-infinite tissue volume with a flat surface, which affects the image reconstruction accuracy for tissues with irregular geometries. An advanced photometric stereo technique (PST) was integrated into the scDCT system to obtain the surface geometry in real time for image reconstruction. Computer simulations demonstrated that a priori knowledge of tissue surface geometry is crucial for precisely reconstructing the anomaly with blood flow contrast. Importantly, the innovative integration design with one single- EMCCD camera for both PST and scDCT data collection obviates the need for offline alignment of sources and detectors on the tissue boundary. The in vivo imaging capability of the updated scDCT is demonstrated by imaging dynamic changes in forearm blood flow distribution during a cuff-occlusion procedure. The feasibility and safety in clinical use are evidenced by intraoperative imaging of mastectomy skin flaps and comparison with fluorescence angiography. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
7. Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes
- Author
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E Johnson, Chong Huang, Li Chen, Mahesh Kudrimoti, Sameera S. Kumar, Brent J. Shelton, Guoqiang Yu, Lixin Dong, Daniel Irwin, Scott D. Stevens, and Yu Shang
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biomedical Engineering ,Urology ,Hemodynamics ,01 natural sciences ,010309 optics ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Research Papers: General ,0103 physical sciences ,medicine ,Humans ,Oxygen saturation (medicine) ,Receiver operating characteristic ,business.industry ,Head and neck cancer ,Chemoradiotherapy ,Blood flow ,medicine.disease ,Primary tumor ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Surgery ,Radiation therapy ,Treatment Outcome ,medicine.anatomical_structure ,Head and Neck Neoplasms ,Cervical lymph nodes ,Oxyhemoglobins ,030220 oncology & carcinogenesis ,business - Abstract
This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n=29) and incomplete response (IR) (n=18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO2]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μs′) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96.
- Published
- 2016
8. Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device
- Author
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Joshua Paul Morgan, Jeffrey Todd Hastings, Jae Gwan Kim, Siavash Mazdeyasna, Chong Huang, Guoqiang Yu, and Myeongsu Seong
- Subjects
Materials science ,Biomedical Engineering ,02 engineering and technology ,01 natural sciences ,Imaging phantom ,Flow measurement ,law.invention ,Semiconductor laser theory ,010309 optics ,Biomaterials ,Speckle pattern ,Optics ,law ,0103 physical sciences ,Laser-Doppler Flowmetry ,Humans ,Spectroscopy ,Laser diode ,Phantoms, Imaging ,business.industry ,Spectrum Analysis ,Hemodynamics ,Blood flow ,JBO Letters ,021001 nanoscience & nanotechnology ,Laser ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Forearm ,Regional Blood Flow ,0210 nano-technology ,business - Abstract
We report a low-cost compact diffuse speckle contrast flowmeter (DSCF) consisting of a small laser diode and a bare charge-coupled-device (CCD) chip, which can be used for contact measurements of blood flow variations in relatively deep tissues (up to ∼ 8 mm). Measurements of large flow variations by the contact DSCF probe are compared to a noncontact CCD-based diffuse speckle contrast spectroscopy and a standard contact diffuse correlation spectroscopy in tissue phantoms and a human forearm. Bland–Altman analysis shows no significant bias with good limits of agreement among these measurements: 96.5%±2.2% (94.4% to 100.0%) in phantom experiments and 92.8% in the forearm test. The relatively lower limit of agreement observed in the in vivo measurements (92.8%) is likely due to heterogeneous reactive responses of blood flow in different regions/volumes of the forearm tissues measured by different probes. The low-cost compact DSCF device holds great potential to be broadly used for continuous and longitudinal monitoring of blood flow alterations in ischemic/hypoxic tissues, which are usually associated with various vascular diseases.
- Published
- 2016
9. Diffuse optical measurements of head and neck tumor hemodynamics for early prediction of chemoradiation therapy outcomes.
- Author
-
Lixin Dong, Kudrimoti, Mahesh, Irwin, Daniel, Li Chen, Kumar, Sameera, Yu Shang, Chong Huang, Johnson, Ellis L., Stevens, Scott D., Shelton, Brent J., and Guoqiang Yu
- Subjects
INFRARED imaging ,HEAD & neck cancer diagnosis ,HEAD & neck cancer treatment ,NECK injuries ,SHRUNKEN heads ,TREATMENT effectiveness - Abstract
This study used a hybrid near-infrared diffuse optical instrument to monitor tumor hemodynamic responses to chemoradiation therapy for early prediction of treatment outcomes in patients with head and neck cancer. Forty-seven patients were measured once per week to evaluate the hemodynamic status of clinically involved cervical lymph nodes as surrogates for the primary tumor response. Patients were classified into two groups: complete response (CR) (n = 29) and incomplete response (IR) (n = 18). Tumor hemodynamic responses were found to be associated with clinical outcomes (CR/IR), wherein the associations differed depending on human papillomavirus (HPV-16) status. In HPV-16 positive patients, significantly lower levels in tumor oxygenated hemoglobin concentration ([HbO
2 ]) at weeks 1 to 3, total hemoglobin concentration at week 3, and blood oxygen saturation (StO2 ) at week 3 were found in the IR group. In HPV-16 negative patients, significantly higher levels in tumor blood flow index and reduced scattering coefficient (μ's ) at week 3 were observed in the IR group. These hemodynamic parameters exhibited significantly high accuracy for early prediction of clinical outcomes, within the first three weeks of therapy, with the areas under the receiver operating characteristic curves (AUCs) ranging from 0.83 to 0.96. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
10. Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device.
- Author
-
Chong Huang, Myeongsu Seong, Morgan, Joshua Paul, Mazdeyasna, Siavash, Jae Gwan Kim, Hastings, Jeffrey Todd, and Guoqiang Yu
- Subjects
FLOW meters ,DIAGNOSTIC imaging ,BLOOD flow measurement ,BLOOD circulation measurement ,FLOW measurement - Abstract
We report a low-cost compact diffuse speckle contrast flowmeter (DSCF) consisting of a small laser diode and a bare charge-coupled-device (CCD) chip, which can be used for contact measurements of blood flow variations in relatively deep tissues (up to ∼8 mm). Measurements of large flow variations by the contact DSCF probe are compared to a noncontact CCD-based diffuse speckle contrast spectroscopy and a standard contact diffuse correlation spectroscopy in tissue phantoms and a human forearm. Bland-Altman analysis shows no significant bias with good limits of agreement among these measurements: 96.5% ± 2.2% (94.4% to 100.0%) in phantom experiments and 92.8% in the forearm test. The relatively lower limit of agreement observed in the in vivo measurements (92.8%) is likely due to heterogeneous reactive responses of blood flow in different regions/volumes of the forearm tissues measured by different probes. The low-cost compact DSCF device holds great potential to be broadly used for continuous and longitudinal monitoring of blood flow alterations in ischemic/hypoxic tissues, which are usually associated with various vascular diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
11. Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise.
- Author
-
Henry, Brad, Mingjun Zhao, Yu Shang, Uhl, Timothy, Thomas, D. Travis, Xenos, Eleftherios S., Saha, Sibu P., and Guoqiang Yu
- Subjects
HEMODYNAMICS ,BLOOD circulation ,OXYGENATORS ,BLOOD flow ,BODY fluid flow - Abstract
Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of forearm muscle hemodynamics during handgrip exercises. The translation of these techniques from the forearm to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin concentrations, blood oxygen saturation, and relative changes in blood flow (rBF) and oxygen consumption rate (r...O
2 ). We calibrated rBF and r...O2 profiles with absolute baseline values of BF and ...O2 obtained by venous and arterial occlusions, respectively. Results from this investigation were comparable to values from similar studies. Additionally, significant correlation was observed between resting local muscle BF measured by the optical technique and whole limb BF measured concurrently by a strain gauge venous plethysmography. The extensive hemodynamic and metabolic profiles during exercise will allow for future comparison studies to investigate the diagnostic value of hybrid technologies in muscles affected by disease. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
12. Noncontact diffuse correlation tomography of human breast tumor.
- Author
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Lian He, Yu Lin, Chong Huang, Irwin, Daniel, Szabunio, Margaret M., and Guoqiang Yu
- Subjects
BREAST tumor diagnosis ,TOMOGRAPHY ,BLOOD flow ,IMAGE reconstruction ,HEMODYNAMICS ,SURFACE geometry - Abstract
Our first step to adapt our recently developed noncontact diffuse correlation tomography (ncDCT) system for three-dimensional (3-D) imaging of blood flow distribution in human breast tumors is reported. A commercial 3-D camera was used to obtain breast surface geometry, which was then converted to a solid volume mesh. An ncDCT probe scanned over a region of interest on the mesh surface and the measured boundary data were combined with a finite element framework for 3-D image reconstruction of blood flow distribution. This technique was tested in computer simulations and in vivo human breasts with low-grade carcinoma. Results from computer simulations suggest that relatively high accuracy can be achieved when the entire tumor is within the sensitive region of diffuse light. Image reconstruction with a priori knowledge of the tumor volume and location can significantly improve the accuracy in recovery of tumor blood flow contrasts. In vivo imaging results from two breast carcinomas show higher average blood flow contrasts (5.9- and 10.9-fold) in the tumor regions compared to the surrounding tissues, which are comparable with previous findings using diffuse correlation spectroscopy. The ncDCT system has the potential to image blood flow distributions in soft and vulnerable tissues without distorting tissue hemodynamics. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
13. Noncontact diffuse optical assessment of blood flow changes in head and neck free tissue transfer flaps.
- Author
-
Chong Huang, Radabaugh, Jeffrey P., Aouad, Rony K., Yu Lin, Gal, Thomas J., Patel, Amit B., Valentino, Joseph, Yu Shang, and Guoqiang Yu
- Subjects
SURGICAL flaps ,BLOOD flow ,SPECTROMETRY ,HEAD & neck cancer ,SURGICAL anastomosis - Abstract
Knowledge of tissue blood flow (BF) changes after free tissue transfer may enable surgeons to predict the failure of flap thrombosis at an early stage. This study used our recently developed noncontact diffuse correlation spectroscopy to monitor dynamic BF changes in free flaps without getting in contact with the targeted tissue. Eight free flaps were elevated in patients with head and neck cancer; one of the flaps failed. Multiple BF measurements probing the transferred tissue were performed during and post the surgical operation. Postoperative BF values were normalized to the intraoperative baselines (assigning "1") for the calculation of relative BF change (rBF). The rBF changes over the seven successful flaps were 1.89 ± 0.15, 2.26 ± 0.13, and 2.43 ± 0.13 (mean ± standard error), respectively, on postoperative days 2, 4, and 7. These postoperative values were significantly higher than the intraoperative baseline values (p < 0.001), indicating a gradual recovery of flap vascularity after the tissue transfer. By contrast, rBF changes observed from the unsuccessful flaps were 1.14 and 1.34, respectively, on postoperative days 2 and 4, indicating less flow recovery. Measurement of BF recovery after flap anastomosis holds the potential to act early to salvage ischemic flaps. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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