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Start Over Descriptor "GW-9662" Journal journal of biomedical science
2 results on '"GW-9662"'

1. Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord.

Author

Charkhpour, Mohammad, Ghavimi, Hamed, Ghanbarzadeh, Saeed, Yousefi, Bahman, Khorrami, Arash, Mesgari, Mehran, and Hassanzadeh, Kambiz

Subjects
*MORPHINE abuse, *PIOGLITAZONE, *PEROXISOME proliferator-activated receptors, *LABORATORY rats, *CYTOKINE genetics, *INTERLEUKIN-6, *NF-kappa B
Abstract

Background: Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-γ) agonist, on the morphine-induced neuroinflammation in the lumbar region of the male Wistar rat spinal cord. Results: Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin- 1beta, and interleukin 6) and nuclear factor-kappa B activity. Administration of the GW-9662 antagonized the above mentioned effects of the pioglitazone. Conclusions: It is concluded that oral administration of the pioglitazone attenuates morphine-induced tolerance and the neuroinflammation in the lumbar region of the rat spinal cord. This action of the pioglitazone may be, at least in part, due to an interaction with the spinal pro-inflammatory cytokine expression and the nuclear factor-kappa B activity. [ABSTRACT FROM AUTHOR]

Published
2015
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2. Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord

Author

Kambiz Hassanzadeh, Mehran Mesgari, Saeed Ghanbarzadeh, Arash Khorrami, Bahman Yousefi, Mohammad Charkhpour, and Hamed Ghavimi

Subjects
Male, Agonist, PPAR-γ, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Lumbar, Neuroinflammation, Drug tolerance, Internal medicine, medicine, Animals, Pharmacology (medical), GW-9662, Rats, Wistar, Molecular Biology, Inflammation, Biochemistry, medical, Lumbar Vertebrae, Pioglitazone, Morphine, business.industry, Research, Biochemistry (medical), Drug Tolerance, Cell Biology, General Medicine, Spinal cord, Rats, PPAR gamma, Lumbar Spinal Cord, Endocrinology, medicine.anatomical_structure, Spinal Cord, Cytokines, Thiazolidinediones, business, medicine.drug
Abstract

Background Morphine-induced tolerance is associated with the spinal neuroinflammation. The aim of this study was to explore the effects of oral administration of the pioglitazone, the peroxisome proliferator activated receptor gamma (PPAR-γ) agonist, on the morphine-induced neuroinflammation in the lumbar region of the male Wistar rat spinal cord. Results Co-administration of the pioglitazone with morphine not only attenuated morphine-induced tolerance, but also prevented the up-regulation of pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin-1beta, and interleukin 6) and nuclear factor-kappa B activity. Administration of the GW-9662 antagonized the above mentioned effects of the pioglitazone. Conclusions It is concluded that oral administration of the pioglitazone attenuates morphine-induced tolerance and the neuroinflammation in the lumbar region of the rat spinal cord. This action of the pioglitazone may be, at least in part, due to an interaction with the spinal pro-inflammatory cytokine expression and the nuclear factor-kappa B activity.

Published
2015

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