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Background Spinal epidural abscess is a high-risk condition that can lead to paralysis or death. It would be of clinical and prognostic utility to identify which subset of patients with spinal epidural abscess is likely to develop a motor deficit or die within 90 days of discharge. Methods We identified all patients ≥18 years of age who were admitted to our hospital system with a diagnosis of spinal epidural abscess during the period of 1993 to 2016. Explanatory variables were collected retrospectively. Bivariate and multivariable logistic regression was performed using these variables to identify independent predictors of motor deficit and 90-day mortality. Nomograms were then constructed to quantify the risk of these outcomes. Results Of the 1,053 patients we identified with spinal epidural abscess, 362 presented with motor weakness. One hundred and thirty-four patients died within 90 days of discharge, inclusive of those who died during hospitalization. Multivariable logistic regression yielded 8 independent predictors of pre-treatment motor deficit and 8 independent predictors of 90-day mortality. We constructed nomograms that generated a probability of pre-treatment motor deficit or 90-day mortality on the basis of the presence of these factors. Conclusions By quantifying the risk of pre-treatment motor deficit and 90-day mortality, our nomograms may provide useful prognostic information for the treatment team. Timely treatment of neurologically intact patients with a high risk of developing a motor deficit is necessary to avoid residual motor weakness and improve survival. Level of evidence Therapeutic Level IV. See Instructions for Authors for a complete description of Levels of Evidence.

Prompt diagnosis and treatment are critical in spinal epidural abscess, as delay can lead to paralysis or death. The initial management decision for spinal epidural abscess is not always clear, with the literature showing conflicting results. When considering nonoperative management, it is crucial to avoid failure of treatment, given the neurologic compromise incurred through failure. Unfortunately, data regarding risk factors associated with failure are scarce.All patients admitted to our hospital system with a diagnosis of spinal epidural abscess from 1993 to 2016 were identified. Patients who were ≥18 years of age and were initially managed nonoperatively were included. Explanatory variables and outcomes were collected retrospectively. Bivariate and multivariable analyses were performed on these variables to identify independent predictors of failure of nonoperative treatment. A nomogram was constructed to generate a risk of failure based on these predictors.We identified 367 patients who initially underwent nonoperative management. Of these, 99 patients underwent medical management that failed. Multivariable logistic regression yielded 6 independent predictors of failure: a presenting motor deficit, pathologic or compression fracture in affected levels, active malignancy, diabetes mellitus, sensory changes, and dorsal location of abscess. We constructed a nomogram that generates a probability of failure based on the presence of these factors.By quantifying the risk of failure on the basis of the presence of 6 independent predictors of treatment failure, our nomogram may provide a useful tool for the treatment team when weighing the risks and benefits of initial nonoperative treatment compared with operative management.Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.