1. Current management of purpura fulminans: a multicenter study.
- Author
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Warner PM, Kagan RJ, Yakuboff KP, Kemalyan N, Palmieri TL, Greenhalgh DG, Sheridan RL, Mozingo DW, Heimbach DM, Gibran NS, Engrav L, Saffle JR, Edelman LS, and Warden GD
- Subjects
- Adolescent, Adult, Bacteremia etiology, Bacteremia therapy, Child, Child, Preschool, Fasciitis, Necrotizing etiology, Fasciitis, Necrotizing therapy, Humans, Infant, Infant, Newborn, Medical Records, Meningococcal Infections complications, Meningococcal Infections therapy, Retrospective Studies, Streptococcal Infections complications, Streptococcal Infections therapy, Time Factors, Treatment Outcome, United States, Burns complications, IgA Vasculitis etiology, IgA Vasculitis therapy, Soft Tissue Injuries etiology, Soft Tissue Injuries therapy
- Abstract
Seven burn centers performed a 10-yr retrospective chart review of patients diagnosed with purpura fulminans. Patient demographics, etiology, presentation, medical and surgical treatment, and outcome were reviewed. A total of 70 patients were identified. Mean patient age was 13 yr. Neisseria meningitidis was the most common etiologic agent in infants and adolescents whereas Streptococcus commonly afflicted the adult population. Acute management consisted of antibiotic administration, volume resuscitation, ventilatory and inotropic support, with occasional use of corticosteroids (38%) and protein C replacement (9%). Full-thickness skin and soft-tissue necrosis was extensive, requiring skin grafting and amputations in 90% of the patients. One fourth of the patients required amputations of all extremities. Fasciotomies when performed early appeared to limit the level of amputation in 6 of 14 patients. Therefore, fasciotomies during the initial management of these patients may reduce the depth of soft-tissue involvement and the extent of amputations.
- Published
- 2003
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