1. Good clinical and cost outcomes using dexrazoxane to treat accidental epirubicin extravasation.
- Author
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Arroyo, Patricia Araque, Perez, Ruth Ubago, Amalia, Maria, Feijoo, Fernandez, and Hernandez, Miguel Angel Calleja
- Subjects
ANTHRACYCLINES ,DRUG therapy ,EXTRAVASATION ,OXALIPLATIN - Abstract
A 75-year-old man diagnosed with lower esophageal adenocarcinoma suffered from epirubicin extravasation during the second cycle of neoadjuvant chemotherapy with epirubicin and oxaliplatin. A full recovery was achieved after treatment with dexrazoxane (Cardioxane®). This is the first time in our hospital that extravasation of an anthracycline has been treated with dexrazoxane. We used Cardioxane®, approved for the prevention of anthracycline-induced cardiotoxicity, while Savene® is indicated for the treatment of anthracycline extravasation. The treatment was effective, and the selection of Cardioxane® (seven-fold cheaper than Savene®) yielded a cost saving. Consequently, Cardioxane® has been included in our guidelines for anthracycline extravasation. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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