17 results on '"Stabile, G."'
Search Results
2. OPEN IRRIGATED VERSUS CONVENTIONAL LARGE TIP CATHETER IN ATRIAL FIBRILLATION ABLATION IMPACT ON PROCEDURAL SAFETY: 16.6
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Zoppo, F., Bertaglia, E., Tondo, C., Coltella, A., Mantovan, R., Senatore, G., Bottoni, N., Carreras, G., Corò, L., Turco, P., Mantica, M., and Stabile, G.
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- 2007
3. LONG—TERM PERFORMANCE OF CORONARY SINUS LEADS USED FOR CARDIAC RESYNCHRONIZATION THERAPY: POLARITY AND AETIOLOGY ANALYSIS: 14.2
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Bertaglia, E., La Rocca, V., Solimene, F., De Simone, A., Zerbi, F., Pascotto, P., Accogli, M., Iuliano, A., Marras, G., and Stabile, G.
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- 2007
4. ICD PROCEDURES IN PRIMARY PREVENTION OF SUDDEN CARDIAC DEATH: TIME AND FREQUENCY ANALYSIS IN AURA STUDY: 13.6
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De Fabrizio, G., Iuliano, A., Gallo, P., Campanale, G., DʼAgostino, C., De Simone, A., Guarini, P., Campanale, E. G., Ciardiello, C., and Stabile, G.
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- 2007
5. ROLE OF ICD IN PRIMARY PREVENTION PATIENTS: PREDICTIVE PARAMETERS OF APPROPRIATE ICD PROCEDURES (AURA STUDY): 13.5
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DʼAgostino, C., Campanale, G., Iuliano, A., Gallo, P., De Fabrizio, G., Palella, M., Campanale, E. G., Guarini, P., Ciardiello, C., and Stabile, G.
- Published
- 2007
6. Targeted ablation of residual pulmonary vein potentials in atrial fibrillation ablation through ultra-high-density mapping: Insights from the CHARISMA registry.
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Solimene F, Stabile G, Segreti L, Malacrida M, Schillaci V, Rossi P, Bongiorni MG, Shopova G, Cauti FM, Zucchelli G, Arestia A, Bianchi S, Di Cori A, Maddaluno F, De Simone A, and Garcia-Bolao I
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- Humans, Recurrence, Registries, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins surgery
- Abstract
Introduction: Low-voltage activity beyond pulmonary veins (PVs) may contribute to the failure of ablation of atrial fibrillation (AF) in the long term. We aimed to assess the presence of gaps (PVG) and residual potential (residual antral potential [RAP]) within the antral scar by means of an ultra-high-density mapping (UHDM) system., Methods: We studied consecutive patients from the CHARISMA registry who were undergoing AF ablation and had complete characterization of residual PV antral activity. The Lumipoint™ (Boston Scientific) map-analysis tool was used sequentially on each PV component. The ablation endpoint was PV isolation (PVI) and electrical quiescence in the antral region., Results: Fifty-eight cases of AF ablation were analyzed. A total of 86 PVGs in 34 (58.6%) patients and 44 RAPs in 34 patients (58.6%) were found. In 16 (27.6%) cases, we found at least one RAP in patients with complete absence of PV conduction. RAPs showed a lower mean voltage than PVG (0.3 ± 0.2 mV vs. 0.7 ± 0.5 mV, p < .0001), whereas the mean number of electrogram peaks was higher (8.4 ± 1.4 vs. 3.2 ± 1.5, p < .0001). The percentage of patients in whom RAPs were detected through Lumipoint™ was higher than through propagation map analysis (58.6% vs. 36.2%, p = .025). Acute procedural success was 100%, with all PVs successfully isolated and RAPs completely abolished in all study patients. During a mean follow-up of 453 ± 133 days, 6 patients (10.3%) suffered an AF/AT recurrence., Conclusion: Local vulnerabilities in antral lesion sets were easily discernible by means of the UHDM system in both de novo and redo patients when no PV conduction was present., (© 2022 Wiley Periodicals LLC.)
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- 2022
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7. Dielectric-based tissue thickness measured during radiofrequency catheter ablation.
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Schillaci V, Stabile G, Arestia A, Shopova G, Agresta A, Salito A, Giannitti CM, Natalizia A, De Simone A, and Solimene F
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- Heart Atria, Humans, Vena Cava, Inferior diagnostic imaging, Vena Cava, Inferior surgery, Atrial Flutter diagnostic imaging, Atrial Flutter surgery, Catheter Ablation adverse effects
- Abstract
Introduction: A new dielectric-based method (KODEX-EPD mapping system, EPD Solutions, a Philips company) for measuring tissue thickness at the catheter-tissue interface has recently been developed. We reported preliminarydata on real-time catheter-based measuring myocardial wall thickness in vivo, during typical atrial flutter radio frequency ablation., Methods and Results: The study population consisted of 12 consecutive patients, suffering from symptomatic paroxysmal or persistent cavo-tricuspid isthmus dependent, counter clockwise and clockwise AFL, under going a first catheter ablation between April 2021 and November 2021. The new KODEX-EPD function, Wall Viever, was used to calculate atrialwall thickness. The atrial wall thickness was significantly higher closeto the tricuspid annulus than close to the inferior vena cava (3.6 ± 0.5 mm vs 2.4 ± 0.3 mm, p < .001) and a trend towards a progressive decrease of atrial wall thickness was observed moving the mapping catheter from the tricuspidvalve to the inferior vena cava., Conclusions: Thenew KODEX-EPD function, Wall Viever, allowed us to assess atrial wall thickness during atrial flutter radio frequency ablation., (© 2022 Wiley Periodicals LLC.)
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- 2022
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8. Pulmonary vein isolation in atrial fibrillation patients guided by a novel local impedance algorithm: 1-year outcome from the CHARISMA study.
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Solimene F, Giannotti Santoro M, De Simone A, Malacrida M, Stabile G, Pandozi C, Pelargonio G, Cauti FM, Scaglione M, Pecora D, Bongiorni MG, Arestia A, Grimaldi G, Russo M, Narducci ML, and Segreti L
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- Aged, Algorithms, Electric Impedance, Female, Humans, Male, Middle Aged, Recurrence, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins surgery
- Abstract
Background: Highly localized impedance (LI) measurements during atrial fibrillation (AF) ablation have recently emerged as a viable real-time indicator of tissue characteristics and durability of the lesions created. We report the outcomes of acute and long-term clinical evaluation of the new DirectSense algorithm in AF ablation., Methods: Consecutive patients undergoing AF ablation were included in the CHARISMA registry. RF delivery was guided by the DirectSense algorithm, which records the magnitude and time-course of the impedance drop. The ablation endpoint was pulmonary vein isolation (PVI), as assessed by the entrance and exit block., Results: 3556 point-by-point first-pass RF applications of >10 s duration were analyzed in 153 patients (mean age=59 ± 10 years, 70% men, 61% paroxysmal AF, 39% persistent AF). The mean baseline LI was 105 ± 15 Ω before ablation and 92 ± 12 Ω after ablation (p < .0001). Both absolute drops in LI and the time to LI drop (LI drop/τ) were greater at successful ablation sites (n = 3122, 88%) than at ineffective ablation sites (n = 434, 12%) (14 ± 8 Ω vs 6 ± 4 Ω, p < .0001 for LI; 0.73 [0.41-1.25] Ω/s vs. 0.35[0.22-0.59 Ω/s, p < .0001 for LI drop/τ). No major complications occurred during or after the procedures. All PVs had been successfully isolated. During a mean follow-up of 366 ± 130 days, 18 patients (11.8%) suffered an AF/atrial tachycardia recurrence after the 90-day blanking period., Conclusion: The magnitude and time-course of the LI drop during RF delivery were associated with effective lesion formation. This ablation strategy for PVI guided by LI technology proved safe and effective and resulted in a very low rate of AF recurrence over 1-year follow-up., (© 2021 Wiley Periodicals LLC.)
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- 2021
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9. A novel local impedance algorithm to guide effective pulmonary vein isolation in atrial fibrillation patients: Preliminary experience across different ablation sites from the CHARISMA pilot study.
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Segreti L, De Simone A, Schillaci V, Bongiorni MG, Pelargonio G, Pandozi C, Di Cori A, Stabile G, Pepe M, Zucchelli G, Shopova G, De Lucia R, Ferrari C, Casati F, Malacrida M, and Solimene F
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- Algorithms, Electric Impedance, Humans, Pilot Projects, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins diagnostic imaging, Pulmonary Veins surgery
- Abstract
Introduction: Recently, a novel technology able to measure local impedance (LI) and tissue characteristics has been made available for clinical use. This analysis explores the relationships among LI and generator impedance (GI) parameters in atrial fibrillation (AF) patients. Characterization of LI among different ablation spots and procedural success were also evaluated., Methods and Results: Consecutive patients undergoing AF ablation from the CHARISMA registry at five Italian centers were included. A novel radiofrequency (RF) ablation catheter with a dedicated algorithm (DIRECTSENSE™) was used to measure LI and to guide ablation. The ablation endpoint was pulmonary vein (PV) isolation. We analyzed 2219 ablation spots created around PVs in 46 patients for AF ablation. The mean baseline tissue impedance was 105.8 ± 14 Ω for LI versus 91.8 ± 10 Ω for GI (p < .0001). Baseline impedance was homogenous across the PV sites and proved higher in high-voltage areas than in intermediate- and low-voltage areas and the blood pool (p < .001). Both LI and GI displayed a significant drop after RF delivery, and absolute LI drop values were significantly larger than GI drop values (14 ± 8 vs. 3.7 ± 5 Ω, p < .0001). Every 5-point increment in LI drop was associated with successful ablation (odds ratio = 3.05, 95% confidence interval: 2.3-4.1, p < .0001). Conversely, GI drops were not significantly different comparing successful versus unsuccessful sites (3.7 ± 5 vs. 2.8 ± 4 Ω, p = .1099). No steam pops or major complications occurred during or after the procedures. By the end of the procedures, all PVs had been successfully isolated in all patients., Conclusions: The magnitude of the LI drop was more closely associated with effective lesion formation than the GI drop., (© 2020 Wiley Periodicals LLC.)
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- 2020
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10. Reproducibility of pulmonary vein isolation guided by the ablation index: 1-year outcome of the AIR registry.
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Stabile G, Lepillier A, De Ruvo E, Scaglione M, Anselmino M, Sebag F, Pecora D, Gallagher M, Rillo M, Viola G, Rossi L, De Santis V, Landolina M, Castro A, Grimaldi M, Badenco N, Del Greco M, De Simone A, Pisanò E, Abbey S, Lamberti F, Pani A, Zucchelli G, Sgarito G, Dugo D, Bertaglia E, Strisciuglio T, and Solimene F
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- Humans, Prospective Studies, Recurrence, Registries, Reproducibility of Results, Treatment Outcome, Atrial Fibrillation diagnosis, Atrial Fibrillation surgery, Catheter Ablation adverse effects, Pulmonary Veins diagnostic imaging, Pulmonary Veins surgery
- Abstract
Background: Ablation index (AI) is a new lesion quality marker that has been demonstrated to allow a high single-procedure arrhythmia-free survival in single-center studies. This prospective, multi-center study was designed to evaluate the reproducibility of pulmonary vein (PV) isolation guided by the AI., Methods: A total of 490 consecutive patients with paroxysmal (80.4%) and persistent AF underwent first time PV isolation and were divided in four study groups according to operator's preference in choosing the ablation catheter (a contact force (ST) or contact force surround flow (STSF) catheter) and the AI setting (330-450 or 380-500 at anterior wall or posterior wall, respectively)., Results: At 12 months a high rate of freedom from AF recurrences was observed in patients with both paroxysmal and persistent AF (91% vs 83.3%; P = .039). There was no difference in the rate of AF recurrence among the four study groups (4.5% in group ST330-450, 12.2% in group ST 380-500, 14.9% in group STSF330-450, 9.4% in group STSF380-500; P = .083). Recurrence was also similar between patients treated with a ST (8%) or STSF catheter (12.1%; P = .2), and within patients targeting an AI settings of 330 to 450 (10.9%) or 380 to 500 (10.3%; P = .64). In patients with paroxysmal AF, there was no difference (P = .12) in the 1-year freedom from AF recurrence among 14 operators that performed ≥10 ablation procedure., Conclusions: An ablation protocol respecting strict criteria for contiguity and quality lesion resulted in high rate of 1-year freedom from AF recurrence, irrespective of the ablation catheters, AI settings, and operator., (© 2020 Wiley Periodicals LLC.)
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- 2020
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11. Safety and efficacy of pulmonary vein isolation using a surround flow catheter with contact force measurement capabilities: A multicenter registry.
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Stabile G, Di Donna P, Schillaci V, Di Monaco A, Iuliano A, Caponi D, Urraro F, Solimene F, Grimaldi M, and Scaglione M
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- Adult, Aged, Atrial Fibrillation diagnosis, Atrial Fibrillation epidemiology, Catheter Ablation adverse effects, Female, Follow-Up Studies, Humans, Italy epidemiology, Male, Middle Aged, Prospective Studies, Treatment Outcome, Young Adult, Atrial Fibrillation surgery, Catheter Ablation instrumentation, Catheter Ablation methods, Pulmonary Veins surgery, Registries
- Abstract
Introduction: Pulmonary vein (PV) isolation is the cornerstone of catheter ablation in patients with atrial fibrillation (AF). Surround flow and contact force (CF) measurement capabilities might enhance procedure efficacy and safety. We report on the safety and midterm efficacy of a novel ablation catheter for PV isolation in patients with AF., Methods and Results: Two hundred thirty-three consecutive patients (57 ± 11 years, 76% males, 51% with structural heart disease), referred for paroxysmal (157) or persistent (76) AF, underwent PV isolation by a surround flow catheter with CF measurement capability in four centers. Ablation was guided by electroanatomic mapping allowing radiofrequency (RF) energy delivery in the antral region aiming at PV isolation. Mean overall procedure time was 100 ± 42 minutes with a mean fluoroscopy time of 6 ± 5 minutes. Mean ablation time was 31±15 minutes; 99% of the targeted veins were isolated. The mean CF value during ablation was 13 ± 4 g. Intraprocedural early (30 minutes) PV reconnection occurred in 12% PVs, and all PVs were effectively reisolated. One pericardial effusion and five groin hematomas were reported. During a mean follow-up of 12 ± 6 months, 30 (12.9%) (10% paroxysmal AF vs. 18% persistent AF, P = 0.07) patients had an atrial arrhythmias recurrence., Conclusions: In this multicenter registry, RF ablation using a new surround flow catheter, with CF sensor, resulted as feasible, achieving a high rate of isolated PVs. Procedural and fluoroscopy times and success rates were comparable with other techniques with a low complication rate., (© 2017 Wiley Periodicals, Inc.)
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- 2017
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12. Device Longevity in a Contemporary Cohort of ICD/CRT-D Patients Undergoing Device Replacement.
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Zanon F, Martignani C, Ammendola E, Menardi E, Narducci ML, DE Filippo P, Santamaria M, Campana A, Stabile G, Potenza DR, Pastore G, Iori M, LA Rosa C, and Biffi M
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- Aged, Female, Humans, Italy, Kaplan-Meier Estimate, Male, Middle Aged, Prosthesis Design, Risk Factors, Time Factors, Cardiac Resynchronization Therapy, Cardiac Resynchronization Therapy Devices, Defibrillators, Implantable, Device Removal, Electric Countershock instrumentation, Electric Power Supplies, Prosthesis Failure
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Introduction: The longevity of defibrillators (ICD) is extremely important from both a clinical and economic perspective. We studied the reasons for device replacement, the longevity of removed ICD, and the existence of possible factors associated with shorter service life., Methods and Results: Consecutive patients who underwent ICD replacement from March 2013 to May 2015 in 36 Italian centers were included in this analysis. Data on replaced devices were collected. A total of 953 patients were included in this analysis. In 813 (85%) patients the reason for replacement was battery depletion, while 88 (9%) devices were removed for clinical reasons and the remaining 52 because of system failure (i.e., lead or ICD generator failure or a safety advisory indication). The median service life was 5.9 years (25th-75th percentile, 4.9-6.9) for single- and dual-chamber ICD and 4.9 years (25th-75th percentile, 4.0-5.7) for CRT-D. On multivariate analysis, the factors CRT-D device, SC/DC ICD generator from Biotronik, percentage of ventricular pacing, and the occurrence of a system failure were positively associated with a replacement procedure. By contrast, the device from Boston Scientific was an independent protective factor against replacement. Considerable differences were seen in battery duration in both ICD and CRT-D. Specifically, Biotronik devices showed the shortest longevity among ICD and Boston Scientific showed the longest longevity among CRT-D (log-rank test, P < 0.001 for pairwise comparisons)., Conclusion: Several factors were associated with shorter service life of ICD devices: CRT-D, occurrence of system failure and percentage of ventricular pacing. Our results confirmed significant differences among manufacturers., (© The Authors. Journal of Cardiovascular Electrophysiology published by Wiley Periodicals, Inc.)
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- 2016
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13. Updated national multicenter registry on procedural safety of catheter ablation for atrial fibrillation.
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Bertaglia E, Stabile G, Pappone A, Themistoclakis S, Tondo C, De Sanctis V, Soldati E, Tritto M, Solimene F, Grimaldi M, Zoppo F, Pandozi C, Augello G, Calò L, and Pappone C
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- Aged, Atrial Fibrillation diagnosis, Female, Humans, Incidence, Italy epidemiology, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Operative Time, Postoperative Complications epidemiology, Registries, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Treatment Outcome, Atrial Fibrillation surgery, Catheter Ablation adverse effects
- Abstract
Introduction: Despite catheter ablation (CA) becoming an accepted treatment option for symptomatic, drug-resistant atrial fibrillation (AF), safety of this procedure continues to be cause for concern. Aim of the present multicenter registry was to assess the incidence of early CA complications and detect their predictors in a contemporary, unselected AF population, Methods and Results: From January 1, 2011 to December 31, 2011, data from 2,323 consecutive patients who underwent CA (median age 60 [52-67]; 72.3% male) for AF in 29 Italian centers were collected. All major complications occurring to the patient from admission to 30th postprocedural day were recorded. No procedure-related death was observed. Major complications occurred in 94 patients (4.0%): 50 patients (2.2%) suffered vascular access complications; 12 patients (0.5%) developed cardiac tamponade; 14 patients (0.6%) presented with pericarditis; 5 patients (0.2%) had transient ischemic attack; 4 patients had stroke; 3 patients (0.1%) had phrenic nerve paralysis; 3 patients (0.1%) had hemothorax. Other isolated but serious adverse events were documented in 3 patients (0.1%). Female gender (OR 2.643; 95% CI 1.686-4.143; P < 0.0001) and longer procedural duration (OR 2.195; 95% CI 1.388-3.473; P < 0.001) independently predicted a higher risk of complications., Conclusion: Major complications occurred in 4.0% of the CA procedures for AF, with vascular access complications being the most frequent events., (© 2013 Wiley Periodicals, Inc.)
- Published
- 2013
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14. Comparison of ThermoCool® Surround Flow catheter versus ThermoCool® catheter in achieving persistent electrical isolation of pulmonary veins: a pilot study.
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Bertaglia E, Fassini G, Anselmino M, Stabile G, Grandinetti G, De Simone A, Calò L, Pandozi C, Pratola C, Zoppo F, Tondo C, Iuliano A, and Gaita F
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- Aged, Atrial Fibrillation diagnosis, Atrial Fibrillation physiopathology, Catheter Ablation adverse effects, Chi-Square Distribution, Electrophysiologic Techniques, Cardiac, Equipment Design, Female, Humans, Italy, Male, Middle Aged, Pilot Projects, Predictive Value of Tests, Pulmonary Veins physiopathology, Recurrence, Sodium Chloride administration & dosage, Therapeutic Irrigation adverse effects, Time Factors, Treatment Outcome, Atrial Fibrillation surgery, Cardiac Catheters, Catheter Ablation instrumentation, Pulmonary Veins surgery, Therapeutic Irrigation instrumentation
- Abstract
Introduction: Aim of this study was to compare efficacy and safety of the new ThermoCool Surround Flow® catheter (SFc) versus the ThermoCool® (TCc) in achieving persistent circumferential electrical isolation of the pulmonary veins (PVs) in patients with paroxysmal atrial fibrillation (AF)., Methods and Results: This multicenter, randomized, controlled study enrolled patients suffering from paroxysmal AF. Randomization was run in a one-to-one fashion between radiofrequency ablation by TCc or SFc. Aim of PVs ablation was documentation of electrical isolation with exit/entrance block recorded on a circular catheter. Among the 106 enrolled patients, 52 (49.0%) were randomized to TCc and 54 (51.0%) to SFc. Total volume of infused saline solution during the procedure was lower in the SFc than in TCc group (752.7 ± 268.6 mL vs 1,165.9 ± 436.2 mL, P < 0.0001). Number of identified and isolated PVs was similar in the 2 groups. Number of PVs remaining isolated 30 minutes after ablation was higher in the SFc than in TCc group (95.2% vs 90.5%, P < 0.03), mainly driven by acute ablation result in the left PVs (96.1% vs 89.7%, P < 0.04). Complications were seldom and observed only in the TCc group (0% vs 3.84%, P < 0.03). At 6-month follow-up SFc patients reported a trend toward less AF recurrences compared to those in the TCc group (22.9% vs 27.0%, P = 0.69)., Conclusion: PV isolation by SFc lowered the rate of left PV early reconnections and reduced the volume of infused saline solution while maintaining the safety profile of AF ablation., (© 2012 Wiley Periodicals, Inc.)
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- 2013
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15. Determinants of efficacy of atrial pacing in preventing atrial fibrillation recurrences.
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Stabile G, Senatore G, De Simone A, Turco P, Coltorti F, Nocerino P, Vitale DF, and Chiariello M
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- Aged, Aged, 80 and over, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation physiopathology, Bundle of His diagnostic imaging, Bundle of His physiopathology, Echocardiography, Electrocardiography, Female, Follow-Up Studies, Heart Atria diagnostic imaging, Heart Atria physiopathology, Heart Rate, Humans, Male, Middle Aged, Secondary Prevention, Treatment Outcome, Atrial Fibrillation prevention & control, Cardiac Pacing, Artificial
- Abstract
Introduction: Several studies have shown that single or dual site atrial pacing is effective in reducing the frequency of recurrent atrial fibrillation (AF) in selected patients. However, it is still unclear what the best predictors are of long-term efficacy of atrial pacing., Methods and Results: Forty-seven patients with paroxysmal AF requiring demand pacing underwent electrophysiologic study and dual chamber pacemaker implant. After 4 months of follow-up, patients were divided into two groups according to the presence (group 1) or absence (group 2) of symptomatic AF recurrences. Atrial pacing markedly reduced AF recurrences in all patients. Twenty-four patients were free of arrhythmia. The basal state conduction times (CTs) and the incremental conduction times (ICTs), during programmed electric stimulation between the high right atrium (HRA) and the coronary sinus ostium (CSos), but not between the HRA and the His-bundle region, were significantly longer in group 1. There was no statistical difference in the effective refractory period (ERP) recorded at the HRA, the low right atrium (LRA), and the CSos between the two groups, whereas the differences between the greatest and least recorded ERPs measured from the HRA, LRA, and CSos (deltaERP) were significantly greater in group 1 patients. Two parameters were selected by discriminant multivariate analysis, namely deltaCTos (ICT-CT between HRA and CSos) and deltaERP. The first had a greater relative importance in predicting AF recurrence (r2 = 0.33 and r2 = 0.1, respectively)., Conclusion: Single site atrial pacing is effective in reducing AF recurrences, with decreasing efficacy in patients with greater right atrial conduction delay and wider refractoriness dispersion.
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- 1999
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16. Radiofrequency modification of the atrioventricular node in patients with chronic atrial fibrillation: comparison between anterior and posterior approaches.
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Stabile G, Turco P, De Simone A, Coltorti F, and De Matteis C
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- Aged, Atrial Fibrillation physiopathology, Atrioventricular Node physiopathology, Chronic Disease, Cross-Over Studies, Female, Follow-Up Studies, Heart Rate, Humans, Male, Prospective Studies, Safety, Treatment Outcome, Atrial Fibrillation surgery, Atrioventricular Node surgery, Catheter Ablation
- Abstract
Introduction: We compared, in a prospective and randomized fashion with a cross-over design, the anterior and posterior approaches to radiofrequency (RF) modification of the AV node in patients with chronic atrial fibrillation., Methods and Results: Thirty-three patients were randomized to receive first an anterior (group I) or posterior (group II) approach for RF modification of AV nodal conduction. Patients who did not fill the endpoint ventricular rate (< 90 beats/min) were crossed over to the alternative approach. After the anterior approach in group I patients, mean ventricular rate was significantly lower than in group II patients after the posterior approach (79.6 +/- 18.8 beats/min vs 110.8 +/- 16.2 beats/min, P < 0.001). In group I, 14 (82%) of 17 patients fulfilled the endpoint, 1 (6%) had complete AV block, and 2 (12%) were crossed over to the posterior approach fulfilling the endpoint. In group II, 4 (25%) of 16 patients fulfilled the endpoint. No transient or permanent high-degree AV block was observed. Among the 12 patients who were crossed over to the anterior approach, 8 fulfilled the endpoint, whereas 4 had permanent high-degree AV block. RF ablation carried out only in the anterior region was safer than a stepwise approach (6% vs 33% incidence of AV block), even though the difference did not reach statistical significance (P = 0.09)., Conclusion: Posterior AV nodal modification is less effective but safer than anterior AV nodal modification. However, to reduce the incidence of AV block, the anterior approach is preferable to a stepwise approach from the posterior to the anterior zone.
- Published
- 1998
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17. Inappropriate sinus tachycardia after radiofrequency ablation of para-Hisian accessory pathways.
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Pappone C, Stabile G, Oreto G, De Simone A, Rillo M, Mazzone P, Cappato R, and Chierchia S
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- Adolescent, Adult, Atrioventricular Node physiopathology, Female, Humans, Male, Catheter Ablation adverse effects, Tachycardia, Sinus etiology, Wolff-Parkinson-White Syndrome surgery
- Abstract
Introduction: Inappropriate sinus tachycardia (IST) has been observed following radiofrequency ablation (RFA) of the AV nodal fast pathway. This study was aimed to prospectively analyze the incidence and clinical significance of IST following RFA of para-Hisian accessory pathways (APs)., Methods and Results: Twenty-eight patients (pts) with para-Hisian APs underwent RFA. An AP was defined as para-Hisian whenever its atrial and ventricular insertions were associated with a His-bundle potential > or = 0.1 mV. RF current was always delivered at the atrial aspect of the tricuspid annulus, to a site where the His-bundle potential was < 0.15 mV. Time- and frequency-domain analysis of heart rate variability was performed in 22 patients, before and after RFA. Abolition of AP conduction was obtained in all pts, and no AV conduction alteration occurred. Six pts (21.4%) presented with IST 45 to 240 minutes after the ablation procedure. In 5 of them, IST disappeared spontaneously within 72 hours, whereas in 1 pt beta-blockers were required for 2 months. The atrial potential amplitude (1.217 +/- 0.264 mV vs 0.882 +/- 0.173 mV, P = 0.009) and A/V potential amplitude ratio (2.633 vs 1.686, P = 0.05) were significantly higher in pts who developed IST than in those who did not. A marked decrease in heart rate variability was observed only in pts who developed IST., Conclusion: IST is a relatively frequent complication after RFA of para-Hisian APs: it is generally short-lasting and usually does not require any treatment. IST after catheter ablation is likely to depend upon transient parasympathetic denervation of the sinus node.
- Published
- 1997
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