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Start Over Author "Autolitano, A" Journal journal of cardiovascular pharmacology
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2. A comparison of synthetic human and rat ANP administered intracerebroventricularly in freely moving normotensive and hypertensive rats

Author

Frisina N, Giovanni Squadrito, Magri, Achille P. Caputi, Buemi M, Autolitano A, Francesco Squadrito, and R. Sturniolo

Subjects
Male, Mean arterial pressure, medicine.medical_specialty, Intracerebroventricular injection, Drinking, Blood Pressure, Rats, Inbred WKY, chemistry.chemical_compound, Atrial natriuretic peptide, Heart Rate, Internal medicine, Rats, Inbred SHR, Renin–angiotensin system, Heart rate, medicine, Animals, Humans, Water intake, Injections, Intraventricular, Pharmacology, business.industry, Hemodynamics, Rats, Endocrinology, chemistry, Hypertension, cardiovascular system, business, Cardiology and Cardiovascular Medicine, Atrial Natriuretic Factor, Saralasin
Abstract

The effects of intracerebroventricular (i.c.v.) injection of alpha-human atrial natriuretic peptide (alpha-hANP) and alpha-rat atrial natriuretic peptide (alpha-rANP) were studied in normotensive [Wistar-Kyoto (WKY)] and spontaneously hypertensive rats (SHR). Intracerebroventricular injection of alpha-hANP (200, 400, and 800 ng in 5 microliters) did not modify mean arterial pressure (MAP), heart rate (HR), and water intake in both WKY rats and SHR. On the contrary, alpha-rANP (200, 400, and 800 ng in 5 microliters) caused strong dipsogenic, pressor, and bradycardic effects that were greater in hypertensive than in normotensive rats. Saralasin (9 microns in 5 microliters), injected 2 min prior to alpha-rANP, abated these effects, thus indicating an involvement of brain angiotensin. Our results suggest that, at least as far as the cerebral effects of ANP are concerned, some difference exists between alpha-rANP and human atrial natriuretic peptide.

Published
1989

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