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Your search keyword '"Gong SX"' showing total 2 results
Start Over Author "Gong SX" Journal journal of cardiovascular translational research
2 results on '"Gong SX"'

1. Upregulation of eIF2α by m 6 A modification accelerates the proliferation of pulmonary artery smooth muscle cells in MCT-induced pulmonary arterial hypertension rats.

Author

Zhang J, Huang WQ, Zhang YR, Liang N, Li NP, Tan GK, Gong SX, and Wang AP

Subjects
Animals, Male, Cells, Cultured, Adenosine analogs & derivatives, Adenosine metabolism, Methylation, Signal Transduction, RNA, Messenger metabolism, RNA, Messenger genetics, Methyltransferases metabolism, Methyltransferases genetics, Pulmonary Artery metabolism, Pulmonary Artery pathology, Pulmonary Artery drug effects, Cell Proliferation drug effects, Myocytes, Smooth Muscle metabolism, Myocytes, Smooth Muscle pathology, Myocytes, Smooth Muscle drug effects, Eukaryotic Initiation Factor-2 metabolism, Eukaryotic Initiation Factor-2 genetics, Up-Regulation, Disease Models, Animal, Rats, Sprague-Dawley, Muscle, Smooth, Vascular metabolism, Muscle, Smooth, Vascular pathology, Muscle, Smooth, Vascular drug effects, Pulmonary Arterial Hypertension metabolism, Pulmonary Arterial Hypertension chemically induced, Pulmonary Arterial Hypertension pathology, Pulmonary Arterial Hypertension physiopathology, Pulmonary Arterial Hypertension genetics, Monocrotaline toxicity
Abstract

Pulmonary arterial hypertension (PAH) is a malignant cardiovascular disease. Eukaryotic initiation factor 2α (eIF2α) plays an important role in the proliferation of pulmonary artery smooth muscle cells (PASMCs) in hypoxia-induced pulmonary hypertension (HPH) rats. However, the regulatory mechanism of eIF2α remains poorly understood in PAH rats. Here, we discover eIF2α is markedly upregulated in monocrotaline (MCT)-induced PAH rats, eIF2α can be upregulated by mRNA methylation, and upregulated eIF2α can promote PASMC proliferation in MCT-PAH rats. GSK2606414, eIF2α inhibitor, can downregulate the expression of eIF2α and alleviate PASMC proliferation in MCT-PAH rats. And we further discover the mRNA of eIF2α has a common sequence with N 6-methyladenosine (m 6 A) modification by bioinformatics analysis, and the expression of METTL3, WTAP, and YTHDF1 is upregulated in MCT-PAH rats. These findings suggest a potentially novel mechanism by which eIF2α is upregulated by m 6 A modification in MCT-PAH rats, which is involved in the pathogenesis of PAH., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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2. Targeting Vascular Smooth Muscle Cell Senescence: A Novel Strategy for Vascular Diseases.

Author

Lin MJ, Hu SL, Tian Y, Zhang J, Liang N, Sun R, Gong SX, and Wang AP

Subjects
Humans, Muscle, Smooth, Vascular, Cellular Senescence, Myocytes, Smooth Muscle, Atherosclerosis, Hypertension
Abstract

Vascular diseases are a major threat to human health, characterized by high rates of morbidity, mortality, and disability. VSMC senescence contributes to dramatic changes in vascular morphology, structure, and function. A growing number of studies suggest that VSMC senescence is an important pathophysiological mechanism for the development of vascular diseases, including pulmonary hypertension, atherosclerosis, aneurysm, and hypertension. This review summarizes the important role of VSMC senescence and senescence-associated secretory phenotype (SASP) secreted by senescent VSMCs in the pathophysiological process of vascular diseases. Meanwhile, it concludes the progress of antisenescence therapy targeting VSMC senescence or SASP, which provides new strategies for the prevention and treatment of vascular diseases., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2023
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