1. Vps13 and Cdc31/centrin: Puzzling partners in membrane traffic
- Author
-
Myers, Margaret D and Payne, Gregory S
- Subjects
Biochemistry and Cell Biology ,Biological Sciences ,1.1 Normal biological development and functioning ,Underpinning research ,Generic health relevance ,Calcium-Binding Proteins ,Humans ,Protein Transport ,Saccharomyces cerevisiae ,Saccharomyces cerevisiae Proteins ,trans-Golgi Network ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
Yeast Vps13 is a member of a conserved protein family that includes human homologues associated with neurodegenerative and developmental disorders. In this issue, De et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606078) establish direct roles for Vps13 and its surprising binding partner, the calcium-binding centrin Cdc31, in trans-Golgi network (TGN) to endosome traffic and TGN homotypic fusion.
- Published
- 2017