1. Muscle stem cells at a glance.
- Author
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Wang YX, Dumont NA, and Rudnicki MA
- Subjects
- Animals, Cell Differentiation physiology, Cells, Cultured, Immunohistochemistry, Mice, PAX7 Transcription Factor metabolism, Satellite Cells, Skeletal Muscle cytology, Muscle, Skeletal cytology, Stem Cells cytology, Stem Cells metabolism
- Abstract
Muscle stem cells facilitate the long-term regenerative capacity of skeletal muscle. This self-renewing population of satellite cells has only recently been defined through genetic and transplantation experiments. Although muscle stem cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar to other adult stem cells, understanding the molecular regulation of muscle stem cells has significant implications towards the development of pharmacological or cell-based therapies for muscle disorders. This Cell Science at a Glance article and accompanying poster will review satellite cell characteristics and therapeutic potential, and provide an overview of the muscle stem cell hallmarks: quiescence, self-renewal and commitment., (© 2014. Published by The Company of Biologists Ltd.)
- Published
- 2014
- Full Text
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