1. Turning regenerative technologies into treatment to repair myocardial injuries
- Author
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Paolo Di Nardo, Giuseppe Orlando, Anna Maria Maccari, Felicia Carotenuto, Laura Teodori, Luciano Delbono, Carotenuto, F., Teodori, L., Maccari, A. M., Delbono, L., Orlando, G., and Di Nardo, P.
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0301 basic medicine ,medicine.medical_specialty ,medicine.medical_treatment ,cell-biomaterial interaction ,Reviews ,Review ,Regenerative Medicine ,immunomodulation ,Cardiac regeneration ,03 medical and health sciences ,0302 clinical medicine ,Tissue engineering ,cardiac cell therapy ,Animals ,Humans ,Regeneration ,Medicine ,cell‐biomaterial interaction ,Clinical efficacy ,Settore MED/50 ,Intensive care medicine ,cardiac microenvironment ,cardiac regeneration ,tissue engineering ,Tissue Scaffolds ,business.industry ,Myocardium ,Settore BIO/13 ,Translational medicine ,Cardiac muscle ,Cell Biology ,Stem-cell therapy ,030104 developmental biology ,medicine.anatomical_structure ,Cellular Microenvironment ,030220 oncology & carcinogenesis ,Cardiac repair ,Molecular Medicine ,Stem cell ,business ,Stem Cell Transplantation - Abstract
Regenerative therapies including stem cell treatments hold promise to allow curing patients affected by severe cardiac muscle diseases. However, the clinical efficacy of stem cell therapy remains elusive, so far. The two key roadblocks that still need to be overcome are the poor cell engraftment into the injured myocardium and the limited knowledge of the ideal mixture of bioactive factors to be locally delivered for restoring heart function. Thus, therapeutic strategies for cardiac repair are directed to increase the retention and functional integration of transplanted cells in the damaged myocardium or to enhance the endogenous repair mechanisms through cell‐free therapies. In this context, biomaterial‐based technologies and tissue engineering approaches have the potential to dramatically impact cardiac translational medicine. This review intends to offer some consideration on the cell‐based and cell‐free cardiac therapies, their limitations and the possible future developments.
- Published
- 2019
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