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Your search keyword '"Martinho, José M. G."' showing total 2 results
Start Over Author "Martinho, José M. G." Journal journal of chemical education
2 results on '"Martinho, José M. G."'

2. Synthesis of a Biologically Active Oxazol-5-(4H)-one via an Erlenmeyer-Plöchl Reaction.

Author

Rodrigue, Catarina A. B., Martinho, José M. G., and Afonso, Carlos A. M.

Subjects
*CHEMICAL synthesis, *CLICK chemistry, *OXAZOLES, *AZOLES, *BENZYLIDENE compounds
Abstract

The synthesis of (Z)-4-(4-nitrobenzylidene)-2-phenyloxazol-5(4H)-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plöchl reaction in the absence of any additional solvents and is isolated without need of preparative chromatography, yielding up to 97% of product. [ABSTRACT FROM AUTHOR]

Published
2015
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