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Topological indices are numerical numbers assigned to the graph/structure and are useful to predict certain physical/chemical properties. In this paper, we give explicit expressions of novel Banhatti indices, namely, first K Banhatti index B1G, second K Banhatti index B2G, first K hyper-Banhatti index HB1G, second K hyper-Banhatti index HB2G, and K Banhatti harmonic index HbG for hyaluronic acid curcumin and hydroxychloroquine. The multiplicative version of these indices is also computed for these structures.